M
Mary C. Mahony
Researcher at Eastern Virginia Medical School
Publications - 41
Citations - 1385
Mary C. Mahony is an academic researcher from Eastern Virginia Medical School. The author has contributed to research in topics: Sperm & Zona pellucida. The author has an hindex of 22, co-authored 39 publications receiving 1338 citations.
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Evidence that anandamide‐signaling regulates human sperm functions required for fertilization
Herbert Schuel,Lani J. Burkman,Jack Lippes,Kent Crickard,Mary C. Mahony,Andrea Giuffrida,Robert P. Picone,Alexandros Makriyannis +7 more
TL;DR: It is reported that AEA is present in human seminal plasma, mid‐cycle oviductal fluid, and follicular fluid analyzed by high‐performance liquid chromatography/mass spectrometry, and imply that smoking of marijuana could impact these processes.
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Modulation of sperm tail protein tyrosine phosphorylation by pentoxifylline and its correlation with hyperactivated motility
TL;DR: Pentoxifylline stimulates sperm functions that are essential to achieving fertilization under in vitro conditions in sperm obtained from fertile men, suggesting a causal relation and the involvement of a modulatory effect after cyclic adenosine monophosphate-dependent phosphorylation of intermediate proteins.
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Protein Tyrosine Phosphorylation during Hyperactivated Motility of Cynomolgus Monkey (Macaca fascicularis) Spermatozoa
Mary C. Mahony,TanYa M. Gwathmey +1 more
TL;DR: It is demonstrated that tyrosine phosphorylation of sperm tail proteins is an integral signaling pathway modulating some but not all of the motion characteristics associated with cAMP- and caffeine-stimulated HA in cynomolgus monkey spermatozoa.
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Effects of hydrogen peroxide on human spermatozoa.
TL;DR: These experiments show that H2O2 directly affects sperm functions crucial to fertilization in a dose-and time-dependent fashion and is probably dependent on modifications of plasma membrane and intraceliular homeostasis by the oxidative process.
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Clinical significance of human sperm-zona pellucida binding
TL;DR: Sperm morphology and hyperactivated motility showed a high correlation with the capacity of sperm to achieve tight binding to the ZP, providing additional support for the use of this functional bioassay in the decision-making process within the assisted reproduction setting.