M
Mary E.D. Flowers
Researcher at Fred Hutchinson Cancer Research Center
Publications - 161
Citations - 14812
Mary E.D. Flowers is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Transplantation & Graft-versus-host disease. The author has an hindex of 55, co-authored 155 publications receiving 13565 citations. Previous affiliations of Mary E.D. Flowers include Leipzig University & National Institutes of Health.
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Journal ArticleDOI
HLA-Haploidentical Bone Marrow Transplantation for Hematologic Malignancies Using Nonmyeloablative Conditioning and High-Dose, Posttransplantation Cyclophosphamide
Leo Luznik,Paul O'Donnell,Paul O'Donnell,Heather J. Symons,Allen R. Chen,M. Susan Leffell,Marianna Zahurak,Ted Gooley,Ted Gooley,S Piantadosi,Michele Kaup,Richard F. Ambinder,Carol Ann Huff,William Matsui,Javier Bolaños-Meade,Ivan Borrello,Jonathan D. Powell,Elizabeth Harrington,Sandy Warnock,Mary E.D. Flowers,Mary E.D. Flowers,Robert A. Brodsky,Brenda M. Sandmaier,Brenda M. Sandmaier,Rainer Storb,Rainer Storb,Richard J. Jones,Ephraim J. Fuchs +27 more
TL;DR: Nonmyeloablative HLA-haploidentical BMT with posttransplantation Cy is associated with acceptable rates of fatal graft failure and severe aGVHD or cGVHD, and there was a trend toward a lower risk of extensive chronic GVHD (cGVHD) among recipients of 2 versus 1 dose of posttrans transplantation Cy.
Journal ArticleDOI
Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects
Peter A. McSweeney,Peter A. McSweeney,Peter A. McSweeney,Dietger Niederwieser,Dietger Niederwieser,Dietger Niederwieser,Judith A. Shizuru,Judith A. Shizuru,Judith A. Shizuru,Brenda M. Sandmaier,Brenda M. Sandmaier,Brenda M. Sandmaier,Arthur J. Molina,Arthur J. Molina,Arthur J. Molina,David G. Maloney,David G. Maloney,David G. Maloney,Thomas R. Chauncey,Thomas R. Chauncey,Thomas R. Chauncey,Ted Gooley,Ted Gooley,Ted Gooley,U Hegenbart,U Hegenbart,U Hegenbart,Richard A. Nash,Richard A. Nash,Richard A. Nash,Jerald P. Radich,Jerald P. Radich,Jerald P. Radich,John L. Wagner,John L. Wagner,John L. Wagner,Steven Minor,Steven Minor,Steven Minor,Frederick R. Appelbaum,Frederick R. Appelbaum,Frederick R. Appelbaum,William I. Bensinger,William I. Bensinger,William I. Bensinger,Eileen Bryant,Eileen Bryant,Eileen Bryant,Mary E.D. Flowers,Mary E.D. Flowers,Mary E.D. Flowers,George E. Georges,George E. Georges,George E. Georges,F. Carl Grumet,F. Carl Grumet,F. Carl Grumet,Hans-Peter Kiem,Hans-Peter Kiem,Hans-Peter Kiem,Beverly Torok-Storb,Beverly Torok-Storb,Beverly Torok-Storb,Cong Yu,Cong Yu,Cong Yu,Karl G. Blume,Karl G. Blume,Karl G. Blume,Rainer Storb,Rainer Storb,Rainer Storb +71 more
TL;DR: A novel allografting approach, based on the use of postgrafting immunosuppression to control graft rejection and GVHD, has dramatically reduced the acute toxicities of allogRAFTing.
Journal ArticleDOI
Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers
William I. Bensinger,Paul J. Martin,Barry E. Storer,Reginald A. Clift,Steven J. Forman,Robert S. Negrin,Ashwin Kashyap,Mary E.D. Flowers,K Lilleby,Thomas R. Chauncey,Rainer Storb,Frederick R. Appelbaum +11 more
TL;DR: In patients given high-dose chemotherapy, with or without radiation, for the treatment of hematologic cancer,allogeneic peripheral-blood cells used for hematopoietic rescue restore blood counts faster than allogeneic bone marrow, without increasing the risk of graft-versus-host disease.
Journal Article
Chronic graft-versus-host disease and other late complications of bone marrow transplantation.
Keith M. Sullivan,Edward Agura,Claudio Anasetti,Frederick R. Appelbaum,Christopher C. Badger,Scott I. Bearman,K Erickson,Mary E.D. Flowers,J.A. Hansen,Thomas P. Loughran +9 more
Journal ArticleDOI
Risk factors for acute GVHD and survival after hematopoietic cell transplantation.
Madan Jagasia,Mukta Arora,Mary E.D. Flowers,Nelson J. Chao,Philip L. McCarthy,Corey Cutler,Alvaro Urbano-Ispizua,Steven Z. Pavletic,Michael Haagenson,Mei-Jie Zhang,Joseph H. Antin,Brian J. Bolwell,Christopher Bredeson,Jean-Yves Cahn,Mitchell S. Cairo,Robert Peter Gale,Vikas Gupta,Stephanie J. Lee,Mark R. Litzow,Daniel J. Weisdorf,Mary M. Horowitz,Theresa Hahn +21 more
TL;DR: Conditioning intensity, TBI and graft source have a combined effect on risk of AGVHD that must be considered in deciding on a treatment strategy for individual patients.