Mary Gerhart

TL;DR: The results should facilitate the development of therapeutically useful inhibitors of TNF-α release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins.

TL;DR: The identification of a distinct receptor for TRAIL, TRAIL‐R2, by ligand‐based affinity purification and subsequent molecular cloning suggests an unexpected complexity to TRAIL biology, reminiscent of dual receptors for TNF, the canonical member of this family.

TL;DR: A broad role for TACE in the regulated shedding of EGFR ligands is supported, showing that cells lacking TACE activity shed dramatically less TGF-α as compared with wild-type cultures and that T GF-α cleavage was partially restored by infection of Tace-deficient cells with TACE-encoding adenovirus.

TL;DR: Comparisons between new proteins that share homology with the signaling domain of the type I interleukin-1 receptor and known IL-1RI homologous proteins revealed six clusters of amino acid similarity, indicating that the sequence homology between IL- 1RI and T1/ST2 indicates a functional homology as well.

TL;DR: This work shows the "35K" virulence gene in variola and cowpox viruses, whose vaccinia and Shope fibroma virus equivalents are strongly conserved in sequence, actually encodes a secreted soluble protein with high-affinity binding to virtually all known beta chemokines, but only weak or no affinity to the alpha and gamma classes.