M
Mary L Ferguson
Researcher at Drexel University
Publications - 7
Citations - 196
Mary L Ferguson is an academic researcher from Drexel University. The author has contributed to research in topics: Antibacterial agent & Biological activity. The author has an hindex of 6, co-authored 7 publications receiving 185 citations.
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Journal ArticleDOI
Polybiguanides, particularly polyethylene hexamethylene biguanide, have activity against human immunodeficiency virus type 1.
Fred C. Krebs,Shendra R. Miller,Mary L Ferguson,Mohamed E. Labib,Robert F. Rando,Brian Wigdahl +5 more
TL;DR: In this article, modified versions of polyhexamethylene biguanide (PHMB) incorporating length changes in the hydrocarbon linker units were synthesized and evaluated for in vitro cytotoxicity and inhibition of HIV-1 infectivity.
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Comparative Safety Evaluation of the Candidate Vaginal Microbicide C31G
Bradley J. Catalone,Tina M. Kish-Catalone,Elizabeth B. Neely,Lynn R. Budgeon,Mary L Ferguson,Catherine Stiller,Shendra R. Miller,Daniel Malamud,Fred C. Krebs,Mary K. Howett,Brian Wigdahl +10 more
TL;DR: The Swiss Webster mouse model was able to effectively discriminate between concentrations and formulations of C31G that produced distinct clinical effects in human trials and may be a highly valuable tool for preclinical evaluation of candidate vaginal microbicides.
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Structure-activity relationships of polybiguanides with activity against human immunodeficiency virus type 1
Shendra Passic,Mary L Ferguson,Bradley J. Catalone,Tina Kish-Catalone,Vladyslav Kholodovych,Wei Zhu,William J. Welsh,Robert R. Rando,Mary K. Howett,Brian Wigdahl,Mohamed E. Labib,Fred C. Krebs +11 more
TL;DR: These structure-activity investigations increase the understanding of PDBG molecules as agents with activity against HIV-1 and provide the foundation for further preclinical studies of PEHMB and other biguanide-based compounds as antiviral and microbicidal agents.
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Critical Design Features of Phenyl Carboxylate-Containing Polymer Microbicides
Robert F. Rando,Sakae Shin-Etsu Chemical Co. Ltd. Obara,Mark C. Osterling,Marie K. Mankowski,Shendra R. Miller,Mary L Ferguson,Fred C. Krebs,Brian Wigdahl,Mohamed E. Labib,Hiroyasu Kokubo +9 more
TL;DR: HPMCT is found to be a potent inhibitor of CXCR4, CCR5, and dual tropic strains of human immunodeficiency virus in peripheral blood mononuclear cells and demonstrates the need to optimize any prospective polymer microbicide with respect to pH considerations and the degree of acid substitution.
Journal ArticleDOI
Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31G.
Bradley J. Catalone,Shendra R. Miller,Mary L Ferguson,Daniel Malamud,Tina Kish-Catalone,Nina Thakkar,Fred C. Krebs,Mary K. Howett,Brian Wigdahl +8 more
TL;DR: In this paper, in vitro assays of cytotoxicity and anti-HIV-1 activity demonstrated that C16B was slightly less cytotoxic compared to either C31G or C14AO.