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Mary W. Baum

Bio: Mary W. Baum is an academic researcher. The author has contributed to research in topics: Deuterium NMR & Deuterium. The author has an hindex of 6, co-authored 9 publications receiving 308 citations.

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Journal ArticleDOI
TL;DR: In this paper, the primary or secondary kinetic isotope effects for a broad variety of reaction types are described to illustrate the use of natural abundance deuterium NMR spectroscopy.
Abstract: Natural abundance deuterium NMR spectroscopy is a powerful and convenient tool for the estimation of deuterium kinetic isotope effects in organic reactions, obviating in many cases the preparation of isotopically enriched reactants for such measurements. Determination of the primary or secondary kinetic isotope effects for a broad variety of reaction types are described to illustrate this technique.

41 citations

Journal ArticleDOI
TL;DR: In this article, the usefulness of /sup 2/H NMR spectroscopy for measuring natural-abundance deuterium isotope effects is demonstrated, using the spectrum of dimethly 2-cyclohexylmalonate prepared by the photolysis of dimethyldiazomalonate in excess cyclohexane.
Abstract: The usefulness of /sup 2/H NMR spectroscopy for measuring natural-abundance deuterium isotope effects is demonstrated. The spectrum of dimethly 2-cyclohexylmalonate prepared by the photolysis of dimethyldiazomalonate in excess cyclohexane illustrates that isotope effects can be measured easily because the H from the ruptured CH bond is retained in the product (results are compared with those of an experiment using 1:1 cyclohexane:cyclohexane-d/sub 12/ as solvent). In the instance of reactions in which CH cleavage results in loss of H to the solvent, the amount of transferred hydrogen must be obtained indirectly. An example of such a reaction is included.

22 citations


Cited by
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Journal ArticleDOI
TL;DR: The method offers advantages of direct incorporation of functional biological molecules into the conducting-polymer nanowires during its synthesis, site-specific positioning, built-in electrical contacts, and scalability to high-density nanoarrays over the reported silicon nanowire and carbon nanotube biosensors.
Abstract: A simple, one-step method for fabricating single biologically functionalized conducting-polymer (polypyrrole) nanowire on prepatterned electrodes and its application to biosensing was demonstrated. The biologically functionalized polypyrrole was formed by the electropolymerization of an aqueous solution of pyrrole monomer and the model biomolecule, avidin- or streptavidin-conjugated ZnSe/CdSe quantum dots, within 100 or 200 nm wide by 3 μm long channels between gold electrodes on prefabricated silicon substrate. When challenged with biotin−DNA, the avidin− and streptavidin−polypyrrole nanowires generated a rapid change in resistance to as low as 1 nM, demonstrating the utility of the biomolecule-functionalized nanowire as biosensor. The method offers advantages of direct incorporation of functional biological molecules into the conducting-polymer nanowire during its synthesis, site-specific positioning, built-in electrical contacts, and scalability to high-density nanoarrays over the reported silicon nano...

370 citations

Journal ArticleDOI
TL;DR: The most common and reliable methods for the reduction of aldehydes, ketones, carboxylic acids, esters, amides, imides, and acid chlorides are discussed.

322 citations

Journal ArticleDOI
TL;DR: In this article, major advances have been made towards dcsign, realization, and optimization of efficient catalytic systems based on modified aluminosilicate mincrals, and a number of optimizations have been proposed.
Abstract: Major advances have been made towards dcsign, realization, and optimization of efficient catalytic systems based on modified aluminosilicate mincrals.

305 citations

Journal ArticleDOI
TL;DR: In this article, eine enantioselektivitat kann in der durch komplexe chirale Oxazaborolidine katalysierten Reduktion von Ketonen erreicht werden.
Abstract: Eine hohe Enantioselektivitat kann in der durch komplexe chirale Oxazaborolidine katalysierten Reduktion von Ketonen erreicht werden. Der Katalysator aktiviert im Ubergangszustand die beiden Reaktanten und halt sie in enger Nachbarschaft zueinander (siehe Schema unten).

294 citations