M
Masaharu Noda
Researcher at National Institute for Basic Biology, Japan
Publications - 186
Citations - 22041
Masaharu Noda is an academic researcher from National Institute for Basic Biology, Japan. The author has contributed to research in topics: Protein tyrosine phosphatase & Complementary DNA. The author has an hindex of 69, co-authored 182 publications receiving 21168 citations. Previous affiliations of Masaharu Noda include Max Planck Society & Kyoto University.
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Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.
Masaharu Noda,Shin Shimizu,Tsutomu Tanabe,Toshiyuki Takai,Toshiaki Kayano,Takayuki Ikeda,Hideo Takahashi,Hitoshi Nakayama,Yuichi Kanaoka,Naoto Minamino,Kenji Kangawa,Hisayuki Matsuo,Michael A. Raftery,Tadaaki Hirose,Seiichi Inayama,Hidenori Hayashida,Takashi Miyata,Shosaku Numa +17 more
TL;DR: Cloning and sequence analysis of cDNA for the Electrophorus electricus electroplax sodium channel indicate that this protein exhibits four repeated homology units, which are presumably oriented in a pseudosymmetric fashion across the membrane.
Journal ArticleDOI
Structural parts involved in activation and inactivation of the sodium channel.
Walter Stühmer,Franco Conti,Harukazu Suzuki,Xiaodong Wang,Masaharu Noda,Naoki Yahagi,Hideo Kubo,Shosaku Numa +7 more
TL;DR: Evidence is provided that the positive charges in segment S4 are involved in the voltage–sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.
Journal ArticleDOI
Molecular distinction between fetal and adult forms of muscle acetylcholine receptor
Masayoshi Mishina,Toshiyuki Takai,Keiji Imoto,Masaharu Noda,Tomoyuki Takahashi,Shosaku Numa,Christoph Methfessel,Bert Sakmann +7 more
TL;DR: The conductance and gating properties of the two classes of channels suggest that replacement of the γ-subunit by the ε- subunit is responsible for the functional alteration of the receptor during muscle development.
Journal ArticleDOI
Existence of distinct sodium channel messenger RNAs in rat brain
Masaharu Noda,Takayuki Ikeda,Toshiaki Kayano,Harukazu Suzuki,Hiroshi Takeshima,Mika Kurasaki,Hideo Takahashi,Shosaku Numa +7 more
TL;DR: In this article, the primary structure of the Electrophorus sodium channel has been elucidated by cloning and sequencing the DNA complementary to its messenger RNA, as deduced from the cDNA sequences.
Journal ArticleDOI
Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin
Masaharu Noda,Yasuji Furutani,Hideo Takahashi,Mitsuyoshi Toyosato,Tadaaki Hirose,Seiichi Inayama,Shigetada Nakanishi,Shosaku Numa +7 more
TL;DR: The nucleotide sequence of cloned cDNA for preproenkephalin from bovine adrenal medulla indicates that the precursor protein contains four copies of Met-enke PHalin, a previously undetected opioid peptide.