Masahiko Kuroda

TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.

TL;DR: Compared with the wild type, mouse embryonic fibroblasts derived from chop -/- animals exhibited significantly less programmed cell death when challenged with agents that perturb ER function, and the proximal tubule epithelium of chop -/+ animals exhibited fourfold lower levels of TUNEL-positive cells, and significantly less evidence for subsequent regeneration.

TL;DR: It is shown that exosomes can efficiently deliver microRNA (miRNA) to epidermal growth factor receptor (EGFR)-expressing breast cancer cells, and the results suggest that exOSomes can be used therapeutically to target EGFR-expressing cancerous tissues with nucleic acid drugs.

TL;DR: The cloning of a murine homolog of yeast IRE1, an essential upstream component of the ER stress‐ response in yeast, is reported on, indicating that a single upstream component, Ire1, plays a role in multiple facets of theER stress‐response in mammalian cells.

TL;DR: The exosome, derived from K562 cells with enforced miR-92a expression, did not affect the growth of HUVECs but did enhance endothelial cell migration and tube formation, supporting the idea that exosomal miRNAs have an important role in neoplasia-to-endothelial cell communication.