M
Masahiro Fuwa
Researcher at SANTEN PHARMACEUTICAL CO., LTD.
Publications - 15
Citations - 454
Masahiro Fuwa is an academic researcher from SANTEN PHARMACEUTICAL CO., LTD.. The author has contributed to research in topics: Genome-wide association study & Agonist. The author has an hindex of 9, co-authored 13 publications receiving 386 citations. Previous affiliations of Masahiro Fuwa include Kyoto Prefectural University of Medicine.
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Journal ArticleDOI
Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population
Masakazu Nakano,Yoko Ikeda,Takazumi Taniguchi,Tomohito Yagi,Masahiro Fuwa,Natsue Omi,Yuichi Tokuda,Masami Tanaka,Kengo Yoshii,Masaaki Kageyama,Shigeta Naruse,Akira Matsuda,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +14 more
TL;DR: It turned out that 3 genetic loci probably associated with POAG have been identified, and these findings would provide the foundation for future studies to build on, such as for the metaanalysis, to reveal the molecular mechanism of the POAG pathogenesis.
Journal ArticleDOI
Common Variants in CDKN2B-AS1 Associated with Optic-Nerve Vulnerability of Glaucoma Identified by Genome-Wide Association Studies in Japanese
Masakazu Nakano,Yoko Ikeda,Yuichi Tokuda,Masahiro Fuwa,Masahiro Fuwa,Natsue Omi,Morio Ueno,Kojiro Imai,Hiroko Adachi,Masaaki Kageyama,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +12 more
TL;DR: POAG-associated variants in the CDKN2B-AS1 locus are identified using a Japanese population and could be associated specifically with the vulnerability of the optic nerve to IOP, which is useful for investigating the etiology of glaucoma.
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Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study.
Mayumi Ueta,Chie Sotozono,Masakazu Nakano,Takazumi Taniguchi,Tomohito Yagi,Yuichi Tokuda,Masahiro Fuwa,Tsutomu Inatomi,Norihiko Yokoi,Kei Tashiro,Shigeru Kinoshita +10 more
TL;DR: It is demonstrated, using both genetic and functional analyses, that EP3 could be a key player in the pathogenesis of SJS/TEN accompanied by ocular complications.
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Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys.
Masahiro Fuwa,Carol B. Toris,Shan Fan,Takazumi Taniguchi,Masaki Ichikawa,Noriko Odani-Kawabata,Ryo Iwamura,Kenji Yoneda,Takeshi Matsugi,Naveed K Shams,Jin-Zhong Zhang +10 more
TL;DR: In this article, the mechanism of the intraocular pressure (IOP)-lowering effect of a novel selective prostaglandin E2 receptor 2 (EP2) receptor agonist, omidenepag isopropyl (OMDI), was investigated.
Journal ArticleDOI
Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population
Masakazu Nakano,Yoko Ikeda,Yuichi Tokuda,Masahiro Fuwa,Morio Ueno,Kojiro Imai,Ryuichi Sato,Natsue Omi,Hiroko Adachi,Masaaki Kageyama,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +12 more
TL;DR: The results suggested that the combination of newly discovered variants in these genes might be useful for precise XFG risk assessment, as well as for elucidating the molecular mechanism of XFG pathogenesis through XFS.