M
Masahiro Sakurai
Researcher at University of Texas Southwestern Medical Center
Publications - 11
Citations - 1338
Masahiro Sakurai is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Blastocyst. The author has an hindex of 9, co-authored 11 publications receiving 898 citations. Previous affiliations of Masahiro Sakurai include Salk Institute for Biological Studies & Universidad Católica San Antonio de Murcia.
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Journal ArticleDOI
Interspecies Chimerism with Mammalian Pluripotent Stem Cells
Jun Wu,Aida Platero-Luengo,Masahiro Sakurai,Atsushi Sugawara,Maria A. Gil,Takayoshi Yamauchi,Keiichiro Suzuki,Y. S. Bogliotti,Cristina Cuello,Mariana Morales Valencia,Daiji Okumura,Jingping Luo,Marcela Vilarino,Inmaculada Parrilla,Delia Alba Soto,Cristina Martínez,Tomoaki Hishida,Sonia Sánchez-Bautista,M. Llanos Martinez-Martinez,Huili Wang,A. Nohalez,Emi Aizawa,Paloma Martinez-Redondo,Alejandro Ocampo,Pradeep Reddy,Jordi Roca,Elizabeth A. Maga,Concepcion Rodriguez Esteban,W. Travis Berggren,Estrella Nuñez Delicado,Jeronimo Lajara,Isabel Guillen,Pedro Guillen,Josep M. Campistol,Emilio A. Martinez,Pablo J. Ross,Juan Carlos Izpisua Belmonte +36 more
TL;DR: A versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing is established and enrichment of rat PSC-derivatives in several tissues of gene-edited organogenesis-disabled mice is shown.
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In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.
Hsin-Kai Liao,Fumiyuki Hatanaka,Toshikazu Araoka,Toshikazu Araoka,Pradeep Reddy,Min-Zu Wu,Min-Zu Wu,Yinghui Sui,Takayoshi Yamauchi,Takayoshi Yamauchi,Masahiro Sakurai,David D. O'Keefe,Estrella Núñez-Delicado,Pedro Guillen,Josep M. Campistol,Cheng-Jang Wu,Li-Fan Lu,Concepcion Rodriguez Esteban,Juan Carlos Izpisua Belmonte +18 more
TL;DR: It is demonstrated that CRISPR/Cas9-mediated target gene activation can be achieved in vivo, leading to measurable phenotypes and amelioration of disease symptoms, and establishes new avenues for developing targeted epigenetic therapies against human diseases.
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Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts.
Y. S. Bogliotti,Jun Wu,Jun Wu,Jun Wu,Marcela Vilarino,Daiji Okamura,Delia Alba Soto,Cuiqing Zhong,Masahiro Sakurai,Masahiro Sakurai,Masahiro Sakurai,R. V. Sampaio,Keiichiro Suzuki,Juan Carlos Izpisua Belmonte,Pablo J. Ross +14 more
TL;DR: It is reported that stable bovine ESCs can be efficiently derived in a culture condition based on Wnt-pathway inhibition and these well-characterized ESC lines will enrich the understanding of pluripotency programs in the ungulate species but also will provide a useful resource for the creation of transgenic ungulates models of human diseases.
Journal ArticleDOI
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.
Ronghui Li,Cuiqing Zhong,Yang Yu,Yang Yu,Haisong Liu,Masahiro Sakurai,Masahiro Sakurai,Leqian Yu,Min Zheying,Lei Shi,Lei Shi,Yulei Wei,Yulei Wei,Yuta Takahashi,Hsin Kai Liao,Hsin Kai Liao,Jie Qiao,Hongkui Deng,Estrella Núñez-Delicado,Concepcion Rodriguez Esteban,Jun Wu,Juan Carlos Izpisua Belmonte +21 more
TL;DR: EPS-blastoids provide a unique platform for studying early embryogenesis and pave the way to creating viable synthetic embryos by using cultured cells through lineage segregation and self-organization.
Journal ArticleDOI
In vivo reprogramming of wound-resident cells generates skin epithelial tissue
Masakazu Kurita,Masakazu Kurita,Toshikazu Araoka,Toshikazu Araoka,Tomoaki Hishida,David D. O'Keefe,Yuta Takahashi,Akihisa Sakamoto,Akihisa Sakamoto,Masahiro Sakurai,Masahiro Sakurai,Keiichiro Suzuki,Jun Wu,Mako Yamamoto,Reyna Hernández-Benítez,Alejandro Ocampo,Pradeep Reddy,Maxim N. Shokhirev,Pierre J. Magistretti,Estrella Nuñez Delicado,Hitomi Eto,Kiyonori Harii,Juan Carlos Izpisua Belmonte +22 more
TL;DR: Alternative supplies of epidermal coverage for the treatment of large cutaneous ulcers are developed and expandable epithelial tissues are generated using in vivo reprogramming of wound-resident mesenchymal cells.