M
Masakatsu Wakeno
Researcher at Osaka University
Publications - 14
Citations - 1183
Masakatsu Wakeno is an academic researcher from Osaka University. The author has contributed to research in topics: Reperfusion injury & Cardioprotection. The author has an hindex of 13, co-authored 14 publications receiving 1113 citations. Previous affiliations of Masakatsu Wakeno include Tokai University.
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Journal ArticleDOI
Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.
Hideyuki Sasaki,Hiroshi Asanuma,Masashi Fujita,Hiroyuki Takahama,Masakatsu Wakeno,Shin Ito,Akiko Ogai,Masanori Asakura,Jiyoong Kim,Tetsuo Minamino,Seiji Takashima,Shoji Sanada,Masaru Sugimachi,Kazuo Komamura,Naoki Mochizuki,Masafumi Kitakaze +15 more
TL;DR: Metformin attenuated oxidative stress–induced cardiomyocyte apoptosis and prevented the progression of heart failure in dogs, along with activation of AMPK, suggesting metformin may be a potential new therapy for heart failure.
Journal ArticleDOI
A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart
Osamu Seguchi,Seiji Takashima,Satoru Yamazaki,Masanori Asakura,Yoshihiro Asano,Yasunori Shintani,Masakatsu Wakeno,Tetsuo Minamino,Hiroya Kondo,Hidehiko Furukawa,Kenji Nakamaru,Asuka Naito,Tomoko Takahashi,Toshiaki Ohtsuka,Koichi Kawakami,Tadashi Isomura,Soichiro Kitamura,Hitonobu Tomoike,Naoki Mochizuki,Masafumi Kitakaze +19 more
TL;DR: In cultured cardiomyocytes, knockdown of cardiac-MLCK by specific siRNAs decreased MLC2v phosphorylation and impaired epinephrine-induced activation of sarcomere reassembly, suggesting a significant role for cardiac- MLCK in cardiogenesis.
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Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs.
Akio Hirata,Tetsuo Minamino,Hiroshi Asanuma,Masashi Fujita,Masakatsu Wakeno,Masafumi Myoishi,Osamu Tsukamoto,Ken-ichiro Okada,Hidekazu Koyama,Kazuo Komamura,Seiji Takashima,Yoshiro Shinozaki,Hidezo Mori,Masamichi Shiraga,Masafumi Kitakaze,Masatsugu Hori +15 more
TL;DR: In addition to its acute infarct size-limiting effect, EPO enhances neovascularization, likely via EPC mobilization, and improves cardiac dysfunction in the chronic phase, although it has time-window limitations.
Journal ArticleDOI
Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning.
Masashi Fujita,Hiroshi Asanuma,Akio Hirata,Masakatsu Wakeno,Hiroyuki Takahama,Hideyuki Sasaki,Jiyoong Kim,Seiji Takashima,Osamu Tsukamoto,Tetsuo Minamino,Yoshiro Shinozaki,Hitonobu Tomoike,Masatsugu Hori,Masafumi Kitakaze +13 more
TL;DR: Postconditioning mediates its cardioprotective effects possibly via prolonged transient acidosis during the early reperfusion phase with the activation of Akt and ERK.
Journal ArticleDOI
Prolonged Targeting of Ischemic/Reperfused Myocardium by Liposomal Adenosine Augments Cardioprotection in Rats
Hiroyuki Takahama,Tetsuo Minamino,Hiroshi Asanuma,Masashi Fujita,Tomohiro Asai,Masakatsu Wakeno,Hideyuki Sasaki,Hiroshi Kikuchi,Kouichi Hashimoto,Naoto Oku,Masanori Asakura,Jiyoong Kim,Seiji Takashima,Kazuo Komamura,Masaru Sugimachi,Naoki Mochizuki,Masafumi Kitakaze +16 more
TL;DR: An infusion as PEGylated liposomes augmented the cardioprotective effects of adenosine against ischemia/reperfusion injury and reduced its unfavorable hemodynamic effects.