In science and technology today, the crucial importance of the regulation of nanoscale objects and structures is well recognized. The production of functional material systems using nanoscale units can be achieved via the fusion of nanotechnology with the other research disciplines. This task is a part of the emerging concept of nanoarchitectonics, which is a concept moving beyond the area of nanotechnology. The concept of nanoarchitectonics is supposed to involve the architecting of functional materials using nanoscale units based on the principles of nanotechnology. In this focus article, the essences of nanotechnology and nanoarchitectonics are first explained, together with their historical backgrounds. Then, several examples of material production based on the concept of nanoarchitectonics are introduced via several approaches: (i) from atomic switches to neuromorphic networks; (ii) from atomic nanostructure control to environmental and energy applications; (iii) from interfacial processes to devices; and (iv) from biomolecular assemblies to life science. Finally, perspectives relating to the final goals of the nanoarchitectonics approach are discussed.

Nanoarchitectonics: what's coming next after nanotechnology?

Incorporation of non-equilibrium actions in the sequence of self-assembly processes would be an effective means to establish bio-like high functionality hierarchical assemblies. As a novel methodology beyond self-assembly, nanoarchitectonics, which has as its aim the fabrication of functional materials systems from nanoscopic units through the methodological fusion of nanotechnology with other scientific disciplines including organic synthesis, supramolecular chemistry, microfabrication, and bio-process, has been applied to this strategy. The application of non-equilibrium factors to conventional self-assembly processes is discussed on the basis of examples of directed assembly, Langmuir-Blodgett assembly, and layer-by-layer assembly. In particular, examples of the fabrication of hierarchical functional structures using bio-active components such as proteins or by the combination of bio-components and two-dimensional nanomaterials, are described. Methodologies described in this review article highlight possible approaches using the nanoarchitectonics concept beyond self-assembly for creation of bio-like higher functionalities and hierarchical structural organization.

Nanoarchitectonics beyond Self‐Assembly: Challenges to Create Bio‐Like Hierarchic Organization

Designing interfacial structures with nanoscale (or molecular) components is one of the important tasks in the nanoarchitectonics concept. In particular, the Langmuir–Blodgett (LB) method can becom...

Don't Forget Langmuir-Blodgett Films 2020: Interfacial Nanoarchitectonics with Molecules, Materials, and Living Objects.

The Langmuir-Blodgett (LB) technique, through which monolayers are transferred from the air/water interface onto a solid substrate, was the first method to allow for the controlled assembly of organic molecules. With its almost 100 year history, it has been the inspiration for most methods to functionalize surfaces and produce nanocoatings, in addition to serving to explore concepts in molecular electronics and nanoarchitectonics. This paper provides an overview of the history of Langmuir monolayers and LB films, including the potential use in devices and a discussion on why LB films are seldom considered for practical applications today. Emphasis is then given to two areas where these films offer unique opportunities, namely, in mimicking cell membrane models and exploiting nanoarchitectonics concepts to produce sensors, investigate molecular recognitions, and assemble molecular machines. The most promising topics for the short- and long-term prospects of the LB technique are also highlighted.

The Past and the Future of Langmuir and Langmuir-Blodgett Films.

Nanoarchitectonics is a concept envisioned to produce functional materials from nanoscale units through fusion of nanotechnology with other scientific disciplines. For component selection, coordina...

Nanoarchitectonics for Coordination Asymmetry and Related Chemistry

Soft and flexible two-dimensional (2D) systems, such as liquid interfaces, would have much more potentials in dynamic regulation on nano-macro connected functions. In this Minireview article, we focus especially on dynamic motional functions at liquid dynamic interfaces as 2D material systems. Several recent examples are selected to be explained for overviewing features and importance of dynamic soft interfaces in a wide range of action systems. The exemplified research systems are mainly classified into three categories: (i) control of microobjects with motional regulations; (ii) control of molecular machines with functions of target discrimination and optical outputs; (iii) control of living cells including molecular machine functions at cell membranes and cell/biomolecular behaviors at liquid interface. Sciences on soft 2D media with motional freedom and their nanoarchitectonics constructions will have increased importance in future technology in addition to popular rigid solid 2D materials.

2D Nanoarchitectonics: Soft Interfacial Media as Playgrounds for Microobjects, Molecular Machines, and Living Cells

The nanoarchitectonics concept enables us to produce functional systems and materials from nanoscale units through nanotechnological approaches together with the processes including chemical syntheses, atom/molecule manipulations, self-assemblies, self-organizations, field-induced material regulations, and bio-related processes. Especially, manipulations of molecules (molecular machines) and sophisticated organization would be attractive targets in interfacial nanoarchitectonics. In this short review, we introduce several typical examples on manipulations of functional molecules and molecular machines at interfacial media. The examples are classified roughly according to driving forces of manipulations; (i) manipulations through chemical reactions and interactions; (ii) light-driven manipulations; (iii) electrically controlled manipulations; (iv) mechanical manipulations. Future possibilities of molecular manipulations at interfaces such as usages in biological systems are discussed in perspective section.

Interfacial nanoarchitectonics for molecular manipulation and molecular machine operation

Molecular behavior and functionality are affected by their prevailing immediate environment. Molecular machines function according to conformational variations and have been studied largely in solu...

Helicity manipulation of a double-paddled binaphthyl in a two-dimensional matrix field at the air-water interface

An air-water interface enables molecular assemblies and conformations to be controlled according to their intrinsic interactions and anisotropic stimuli. The chirality and conformation of binaphthyl derivatives have been controlled by tuning molecular aggregated states in solution. In this study, we have tuned molecular aggregated states of monobinaphthyldurene (MBD) by applying different mechanical stimuli to control the conformation at the air-water interface. Density functional theory calculations indicate that MBD exists essentially in two conformations, namely, 1-MBD (most stable) and 2-MBD (less stable). MBD was mechanically dissolved in appropriate lipid matrices using the Langmuir-Blodgett (LB) method, while pure MBD was self-assembled at the dynamic air-water interface in the absence of or by applying vortex motions (vortex LB method). In MBD mixed monolayer, surface pressure-molecular area measurements and atomic force microscopy observations suggest that separate lipids and MBD phases transform to mixed phases induced by the dissolution of MBD into the lipid matrices during mechanical compression at the air-water interface. Circular dichroism measurements indicate that molecular conformation changes from 1-MBD to 2-MBD in passing from a separated phase to a mixed MBD/lipid phase. In addition, the molecular aggregated states and conformations of MBD depend on the spreading volume and vortex flow rate when applying the vortex LB method. Molecular conformations and aggregated states of MBD could be controlled continuously by applying a mechanical stimulus at the air-water interface.

Masaki Ishii

Papers

2D Nanoarchitectonics: Soft Interfacial Media as Playgrounds for Microobjects, Molecular Machines, and Living Cells

Interfacial nanoarchitectonics for molecular manipulation and molecular machine operation

Helicity manipulation of a double-paddled binaphthyl in a two-dimensional matrix field at the air-water interface

Mechanical Tuning of Aggregated States for Conformation Control of Cyclized Binaphthyl at the Air-Water Interface.