M
Masaru Okabe
Researcher at Osaka University
Publications - 349
Citations - 34447
Masaru Okabe is an academic researcher from Osaka University. The author has contributed to research in topics: Sperm & Transgene. The author has an hindex of 96, co-authored 349 publications receiving 32201 citations. Previous affiliations of Masaru Okabe include National Institute for Basic Biology, Japan & Salk Institute for Biological Studies.
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Journal ArticleDOI
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Katsuaki Hoshino,Tsuneyasu Kaisho,Hideki Sanjo,Osamu Takeuchi,Masanaka Sugiyama,Masaru Okabe,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense and complete loss of nuclear factor kappa B activation in response toTLR4 stimulation is demonstrated.
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Green mice' as a source of ubiquitous green cells
TL;DR: Transgenic mouse lines with an ‘enhanced’ GFP (EGFP) cDNA under the control of a chicken beta‐actin promoter and cytomegalovirus enhancer were produced and all of the tissues from these transgenic lines, with the exception of erythrocytes and hair, were green under excitation light.
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DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes
Satomi Kuramochi-Miyagawa,Toshiaki Watanabe,Kengo Gotoh,Yasushi Totoki,Atsushi Toyoda,Masahito Ikawa,Noriko Asada,Kanako Kojima,Yuka Yamaguchi,Takashi W. Ijiri,Kenichiro Hata,En Li,Yoichi Matsuda,Tohru Kimura,Masaru Okabe,Yoshiyuki Sakaki,Hiroyuki Sasaki,Toru Nakano,Toru Nakano +18 more
TL;DR: In this paper, DNA methylation and Piwi-interacting small RNA (piRNA) expression were analyzed in wild-type, MILI-null, and MIWI2-null male fetal germ cells.
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Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.
Satomi Kuramochi-Miyagawa,Tohru Kimura,Takashi W. Ijiri,Taku Isobe,Noriko Asada,Yukiko Fujita,Masahito Ikawa,Naomi Iwai,Masaru Okabe,Wei Deng,Haifan Lin,Yoichi Matsuda,Toru Nakano +12 more
TL;DR: The similarities in the phenotypes of the MILI- and MVH-deficient mice and in the physical binding properties of MILI and MVh indicate a functional association of these proteins in post-transcriptional regulation, and indicate that MILI is essential for the differentiation of spermatocytes.
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The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs
TL;DR: By using a fusion-inhibiting monoclonal antibody and gene cloning, a mouse sperm fusion-related antigen is identified and it is shown that the antigen is a novel immunoglobulin superfamily protein.