Masashi Fujita

TL;DR: Findings suggest that pressure overload by TAC induces prolonged ER stress, which may contribute to cardiac myocyte apoptosis during progression from cardiac hypertrophy to failure.

TL;DR: Short-term statin therapy improves cardiac function, neurohormonal imbalance, and symptoms associated with idiopathic dilated cardiomyopathy and suggest that statins may have therapeutic benefits in patients with heart failure irrespective of serum cholesterol levels or atherosclerotic heart disease.

TL;DR: Metformin attenuated oxidative stress–induced cardiomyocyte apoptosis and prevented the progression of heart failure in dogs, along with activation of AMPK, suggesting metformin may be a potential new therapy for heart failure.

TL;DR: Natriuretic peptides enhance adiponectin production by human adipocytes in vitro and even in patients with CHF, which might have a beneficial effect on cardiomyocytes in patients receiving recombinant natriureic peptide therapy for heart failure.

TL;DR: Acquiring direct flow based on the angiosome concept is important for limb salvage by EVT in patients with CLI, and it is significantly higher in the direct group than in the indirect group for up to 4 years after the procedure.