Author
Masayuki Kashiwagi
Bio: Masayuki Kashiwagi is an academic researcher from Fukuoka University. The author has contributed to research in topics: Solid-phase microextraction & Derivatization. The author has an hindex of 10, co-authored 49 publications receiving 336 citations.
Papers published on a yearly basis
Papers
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TL;DR: A simple method for hair analysis of methamphetamine (MAMP) and amphetamine (AMP) by gas chromatography-mass spectrometry (GC-MS) was developed using simultaneous headspace solid-phase microextraction (HS-SPME) with derivatization.
54 citations
TL;DR: There was professional error on the part of the doctor in the form of medical malpractice in the case of a 29-year-old woman who died 3.5 hours after undergoing stellate ganglion block (SGB).
25 citations
TL;DR: This method is feasible for the screening of volatile hydrocarbons from blood in forensic medicine and can be used for examining a burned body to ascertain whether the victim had been alive or not when the burning incident took place.
23 citations
TL;DR: Using a detection method that has been rarely utilized to analyze these types of compounds, gas chromatography with positive chemical ionization and tandem mass spectrometry (GC-PCI-MS/MS), 5 psychotropic compounds were detected in an actual forensic autopsy case.
20 citations
TL;DR: The drowning index (DI) was devised to diagnose drowning deaths, and is the weight ratio of the lungs and pleural effusion to the spleen, which is a valuable indicator.
20 citations
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TL;DR: Experimental NeurologyBy Prof. Paul Glees.
Abstract: Experimental Neurology By Prof Paul Glees Pp xii + 532 (Oxford: Clarendon Press; London: Oxford University Press, 1961) 75s net
1,559 citations
TL;DR: Improved chromatographic-mass spectrometric techniques with increased selectivity and sensitivity and new methods of sample preparation have substantially enhanced the ability to detect numerous drugs and other poisons in hair.
908 citations
TL;DR: This paper reviews the recent developments in bioanalysis sample preparation techniques and gives an update on basic principles, theory, applications and possibilities for automation, and a comparative discussion on the advantages and limitation of each technique.
Abstract: This paper reviews the recent developments in bioanalysis sample preparation techniques and gives an update on basic principles, theory, applications and possibilities for automation, and a comparative discussion on the advantages and limitation of each technique. Conventional liquid-liquid extraction (LLE), protein precipitation (PP) and solid-phase extraction (SPE) techniques are now been considered as methods of the past. The last decade has witnessed a rapid development of novel sample preparation techniques in bioanalysis. Developments in SPE techniques such as selective sorbents and in the overall approach to SPE, such as hybrid SPE and molecularly imprinted polymer SPE, have been addressed. Considerable literature has been published in the area of solid-phase micro-extraction and its different versions, e.g. stir bar sorptive extraction, and their application in the development of selective and sensitive bioanalytical methods. Techniques such as dispersive solid-phase extraction, disposable pipette extraction and micro-extraction by packed sorbent offer a variety of extraction phases and provide unique advantages to bioanalytical methods. On-line SPE utilizing column-switching techniques is rapidly gaining acceptance in bioanalytical applications. PP sample preparation techniques such as PP filter plates/tubes offer many advantages like removal of phospholipids and proteins in plasma/serum. Newer approaches to conventional LLE techniques (salting-out LLE) are also covered in this review article.
303 citations
TL;DR: In this paper, a review of sample preparation techniques for forensic, clinical and pharmaceutical analysis, with special focus on in-tube solid-phase microextraction and related new techniques, is presented.
Abstract: Sample preparation is necessary to isolate the desired components from complex matrices, because most analytical instruments cannot handle the matrix directly. Recent trends in sample preparation include miniaturization, automation, high-throughput performance, on-line coupling with analytical instruments and reduction in solvent volume and time. This article reviews recent advances in sample preparation techniques for forensic, clinical and pharmaceutical analysis, with special focus on in-tube solid-phase microextraction and related new techniques.
217 citations
TL;DR: Advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and unstable organic compounds are described.
Abstract: This is the first of a series of reviews on the application of derivatization in mass spectrometry. A description is given of advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and unstable organic compounds. In addition to chemical aspects of silylation, mass spectral properties of silyl derivatives useful for structure determination and quantitation of various organic and biologically-active compounds, mainly by GC/MS, are described. Practically all tested and widely used silylating agents are described. The role of comprehensive libraries containing reference mass spectra for various silyl derivatives and search systems in structure determination is emphasized. Applications of silylation for particular analyses are summarised.
213 citations