M
Masayuki Takahashi
Researcher at Scripps Research Institute
Publications - 20
Citations - 648
Masayuki Takahashi is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: RNA & Allylic rearrangement. The author has an hindex of 13, co-authored 20 publications receiving 641 citations. Previous affiliations of Masayuki Takahashi include Yale University.
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Journal ArticleDOI
Monitoring Molecular Recognition of the Ribosomal Decoding Site
Sarah Shandrick,Qiang Zhao,Qing Han,Benjamin K. Ayida,Masayuki Takahashi,Geoffrey C. Winters,Klaus B. Simonsen,Dionisios Vourloumis,Thomas Hermann +8 more
TL;DR: An internal loop containing adenine residues A1492 and A1493 in 16S rRNA of the 30S (small) ribosomal subunit constitutes a major component of the bacterial decoding site.
Journal ArticleDOI
Solid-phase synthesis of benzimidazole libraries biased for RNA targets
Dionisios Vourloumis,Masayuki Takahashi,Klaus Baek Simonsen,Benjamin K Ayida,Sofia Barluenga,Geoffrey C. Winters,Thomas Hermann +6 more
TL;DR: An efficient and highly versatile synthesis of two libraries 1(x,y) and 2-Ar( x,y,z) or 2-R 2 (x,Y,w) based on the privileged benzimidazole scaffold is described, aimed at obtaining molecules biased for binding to RNA targets by incorporating functionalities, which are frequently found in natural RNA-ligands.
Journal ArticleDOI
Novel paromamine derivatives exploring shallow-groove recognition of ribosomal-decoding-site RNA.
Klaus B. Simonsen,Benjamin K. Ayida,Dionisios Vourloumis,Masayuki Takahashi,Geoffrey C. Winters,Sofia Barluenga,Seema Qamar,Sarah Shandrick,Qiang Zhao,Thomas Hermann +9 more
TL;DR: An in vitro transcription–translation assay of a series of 6‐derivatives showed the 6′‐position to be very sensitive to substitution, which suggests that the group at the 6‐position plays a pivotal role in RNA target recognition.
Journal ArticleDOI
Regio- and Stereoselective Cross-Coupling of Substituted Olefins and Imines. A Convergent Stereoselective Synthesis of Saturated 1,5-Aminoalcohols and Substituted Piperidines
TL;DR: A mild and efficient alkoxide-directed C−C bond-forming reaction is described that provides a regio- and stereoselective route to 1,5-aminoalcohols based on cross-coupling of substituted olefins and imines.
Journal ArticleDOI
Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA.
Dionisios Vourloumis,Masayuki Takahashi,Geoffrey C. Winters,Klaus B. Simonsen,Benjamin K. Ayida,Sofia Barluenga,Seema Qamar,Sarah Shandrick,Qiang Zhao,Thomas Hermann +9 more
TL;DR: The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure and RNA-targeted 2,5-dideoxystreptamine-4-amides are synthesized in which a sugar moiety in natural am inoglycosides is replaced by heterocycles.