M
Masayuki Yamamoto
Researcher at Tohoku University
Publications - 1736
Citations - 140543
Masayuki Yamamoto is an academic researcher from Tohoku University. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 171, co-authored 1576 publications receiving 123028 citations. Previous affiliations of Masayuki Yamamoto include Nitto Denko & Institute of Medical Science.
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Journal ArticleDOI
An nrf2/small maf heterodimer mediates the induction of phase ii detoxifying enzyme genes through antioxidant response elements
Ken Itoh,Tomoki Chiba,Satoru Takahashi,Tetsuro Ishii,Kazuhiko Igarashi,Yasutake Katoh,Tatsuya Oyake,Norio Hayashi,Kimihiko Satoh,Ichiro Hatayama,Masayuki Yamamoto,Yo-ichi Nabeshima +11 more
TL;DR: It is demonstrated that Nrf2 is essential for the transcriptional induction of phase II enzymes and the presence of a coordinate transcriptional regulatory mechanism for phase II enzyme genes and the nrf2-deficient mice may prove to be a very useful model for the in vivo analysis of chemical carcinogenesis and resistance to anti-cancer drugs.
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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Ken Itoh,Nobunao Wakabayashi,Yasutake Katoh,Tetsuro Ishii,Kazuhiko Igarashi,James Douglas Engel,James Douglas Engel,Masayuki Yamamoto +7 more
TL;DR: It is postulate that Keap1 and Nrf2 constitute a crucial cellular sensor for oxidative stress, and together mediate a key step in the signaling pathway that leads to transcriptional activation by this novel NRF2 nuclear shuttling mechanism.
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Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice
Masaaki Komatsu,Satoshi Waguri,Masato Koike,Yu-shin Sou,Yu-shin Sou,Takashi Ueno,Taichi Hara,Noboru Mizushima,Junichi Iwata,Junichi Iwata,Junji Ezaki,Shigeo Murata,Jun Hamazaki,Yasumasa Nishito,Shun-ichiro Iemura,Tohru Natsume,Toru Yanagawa,Junya Uwayama,Eiji Warabi,Hiroshi Yoshida,Tetsuro Ishii,Akira Kobayashi,Masayuki Yamamoto,Zhenyu Yue,Yasuo Uchiyama,Eiki Kominami,Keiji Tanaka +26 more
TL;DR: The findings highlight the unexpected role of homeostatic level of p62, which is regulated by autophagy, in controlling intracellular inclusion body formation, and indicate that the pathologic process associated with autophagic deficiency is cell-type specific.
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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Masaaki Komatsu,Hirofumi Kurokawa,Satoshi Waguri,Keiko Taguchi,Akira Kobayashi,Yoshinobu Ichimura,Yoshinobu Ichimura,Yu-shin Sou,Yu-shin Sou,Izumi Ueno,Ayako Sakamoto,Kit I. Tong,Mihee Kim,Yasumasa Nishito,Shun-ichiro Iemura,Tohru Natsume,Takashi Ueno,Eiki Kominami,Hozumi Motohashi,Keiji Tanaka,Masayuki Yamamoto +20 more
TL;DR: The findings indicate that the pathological process associated with p62 accumulation results in hyperactivation of Nrf2 and delineates unexpected roles of selective autophagy in controlling the transcription of cellular defence enzyme genes.
Journal ArticleDOI
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Akira Kobayashi,Moon Il Kang,Hiromi Okawa,Makiko Ohtsuji,Yukari Zenke,Tomoki Chiba,Kazuhiko Igarashi,Masayuki Yamamoto +7 more
TL;DR: It is found that both the BTB and intervening-region (IVR) domains are crucial for Nrf2 degradation, implying that these two domains act to recruit ubiquitin-proteasome factors.