Masoomeh Ghasemi

Bio: Masoomeh Ghasemi is an academic researcher. The author has contributed to research in topics: Depression (economics) & Anxiety. The author has an hindex of 3, co-authored 4 publications receiving 32 citations.

Simplification of gold nanoparticle synthesis with low cytotoxicity using a greener approach: opening up new possibilities

Abstract: Gold nanoparticles (AuNPs) have diverse applications in the diagnosis and treatment of ailments. This study describes an extremely simplified synthesis of AuNPs using antioxidant-rich pollen extract as a local natural source. Ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to characterize the synthesized AuNPs; strong UV-vis absorption at 534 nm confirmed their formation, the XRD pattern showed the presence of a crystalline structure, and TEM images showed them to be spherical nanoparticles with an average size of 9.3 ± 2.9 nm. As synthesized AuNPs remained stable for up to two months under laboratory conditions without any sedimentation or change in the absorption value, presumably due to the protection afforded by the capping agents from pollen. AuNPs revealed low toxicity effects on MCF-7 and HUVECs cell lines (with an IC50 value of ∼400 μg mL−1 for both the cell lines). The proposed method did not use any hazardous materials or high-energy consuming devices; thus this efficient protocol may be adapted for large-scale production using local resources.

Cytotoxicity properties of plant-mediated synthesized K-doped ZnO nanostructures.

Abstract: In this study, potassium-doped zinc oxide nanoparticles (K-doped ZnO NPs) were green-synthesized using pine pollen extracts based on bioethics principles. The synthesized NPs were analyzed using X-ray diffraction (XRD), inductively coupled plasma atomic emission spectroscopy (ICP-AES), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDXA), and transmission electron microscopy (TEM). The cytotoxicity of these nanoparticles (NPs) on normal macrophage cells and cancer cell lines was evaluated. In the same concentrations of K-doped ZnO and pure ZnO NPs, K-doped ZnO NPs demonstrated higher toxicity. The results confirmed that the doped potassium could increase cytotoxicity. The IC50 of K-doped ZnO NPs, pure ZnO NPs, and the examined control drug were 497 ± 15, 769 ± 12, and 606 ± 19 µg/mL, respectively. Considering the obtained IC50 of K-doped ZnO NPs, they were more toxic to the cancer cell lines and had less cytotoxicity on normal macrophage cells.

Surveying the relationship of Internet addiction with dependence on cell phone, depression, anxiety, and stress in collegians (Case study: Bam University of Medical Sciences)

Abstract: Background and objectives: A considerable increase in using the Internet and cell phone is evident especially among university students. On the other hand, the attention and concerns expressed about the psychological and social effects of long-term use of communicational technologies and the, probably negative, effects on professional future and social relationships are growing. Therefore, the present study is aimed at determining the relationship of Internet addiction with excessive dependence on cell phone, depression, anxiety, and stress in the students of Bam University of Medical Sciences. Methodology: A comparative-correlative study on 230 students in Bam University of Medical Sciences was carried out in 2014. The data was collected using Young's Internet Addiction Test (IAT), dependence of cell phone, and Lovibond & Lovibond's depression, anxiety and stress scale (DASS-21). (sig. = 0.05) Finding: Total scores of Internet addiction and dependence on cell phone were 49.03 +/- 20 and 42.7 +/- 11.77 respectively. There was also a significant relationship between Internet addiction and the variables dependence on cell phone, depression, anxiety, and stress. (p<0.05) Conclusion: The results showed that increase in the time spent on the Internet led to increase in depression, anxiety, stress, and dependence on cell phone. Therefore, there is a need for more efficient educational, consultation, and behavioral planning to attenuate the psychological and social damages.

Comparison of music and vapocoolant spray in reducing the pain of venous cannulation in children age 6-12: a randomized clinical trial

Abstract: Venous cannulation is among the most stressful and painful experiences of children hospitalization. Children with thalassemia need regular blood transfusion which needs venous access each time. The quality of care and quality of life of children will be improved if appropriate methods are used to reduce pain. This study aimed to compare vapocoolant spray and music in the reduction of pain of Venous cannulation in children with thalassemia.The study was a randomized controlled clinical trial with a cross-over design. Thirty-six children with thalassemia from Thalassemia Patients of Pasteur Hospital in Bam from October to December 2020 and were recruited and randomly allocated to two arms. The pain of venous cannulation (no treatment) was measured in the first blood transfusion session as control. In the second and third sessions, two arms received music and vapocoolant spray before the venous cannulation with a cross-over design. The intensity of pain was measured by a Visual Analogue Scale (VAS). The change in pain scores was tested by ANOVA and Tukey post-hoc test between three measurements.During and after the cannulation, the pain was significantly lower in the vapocoolant measurement than in control and music (p < 0.05). There was a significant effect of vapocoolant spray during the procedure F (2, 90) = 25.604, p = 0.001. Also, there was a significant effect of vapocoolant spray after the procedure F (2, 90) = 10.087, p = 0.004). Music did not reduce the pain during cannulation (p = 0.413) and after that (p = 0.807) significantly when compared with control.Vapocoolant was an effective method of pain reduction in the reduction of venous cannulation pain. Music was not effective in the reduction of venous cannulation pain when we compared it with controls. The pain of venous cannulation is rated as high and it can have negative effects on the children. There is a need to do more research on the methods of pain reduction of venous cannulation.The trial is registered: IRCT20111019007844N13, 13/03/2020. Available at: https://en.irct.ir/trial/42904 .

Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine

Abstract: Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the automobile industry. Researchers are now harnessing the catalytic repertoire of CNPs to develop potential new treatment modalities for both oxidative- and nitrosative-stress induced disorders and diseases. In order to reach the point where our experimental understanding of the antioxidant activity of CNPs can be translated into useful therapeutics in the clinic, it is necessary to evaluate the most current evidence that supports CNP antioxidant activity in biological systems. Accordingly, the aims of this review are three-fold: (1) To describe the putative reaction mechanisms and physicochemical surface properties that enable CNPs to both scavenge reactive oxygen species (ROS) and to act as antioxidant enzyme-like mimetics in solution; (2) To provide an overview, with commentary, regarding the most robust design and synthesis pathways for preparing CNPs with catalytic antioxidant activity; (3) To provide the reader with the most up-to-date in vitro and in vivo experimental evidence supporting the ROS-scavenging potential of CNPs in biology and medicine.

The association between smartphone use, stress, and anxiety: A meta-analytic review

Abstract: Research investigating the various mental, physical, and social effects of smartphone use has proliferated in the previous decade. Two variables of interest in this literature are the levels of anxiety and stress associated with smartphone use. The current meta-analysis aimed to provide the first quantitative review of this literature, as well as determine potential moderators that might influence this relationship. A total of 39 independent samples (N = 21, 736) were used to compute a summary effect size of r = .22, p < .001, CI [.17-.28] indicating a small-to-medium association between smartphone use and stress and anxiety. Significant moderators included the year in which the article was published, as well as whether problematic or nonproblematic phone use was assessed. In addition, studies using validated measures of smartphone use indicated a (nonsignificantly) larger association than studies using nonvalidated measures. Strengths and limitations of the meta-analysis, as well as future directions of research are discussed.