M
Massimo Bortolotti
Researcher at University of Bologna
Publications - 51
Citations - 1580
Massimo Bortolotti is an academic researcher from University of Bologna. The author has contributed to research in topics: Immunotoxin & Saporin. The author has an hindex of 18, co-authored 45 publications receiving 1023 citations.
Papers
More filters
Journal ArticleDOI
Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects
TL;DR: positive and negative outcomes concerning cancer pathology have been analyzed because XOR products may induce mutagenesis, cell proliferation, and tumor progression, but they are also associated with apoptosis and cell differentiation.
Journal ArticleDOI
The role of xanthine oxidoreductase and uric acid in metabolic syndrome.
TL;DR: The dual-face role of both XOR and uric acid explains the contradictory results obtained with XOR inhibitors and suggests caution in their therapeutic use.
Journal ArticleDOI
Saporin-S6: A Useful Tool in Cancer Therapy
TL;DR: In this review, some aspects of saporin-S6, such as the chemico-physical characteristics, the structural properties, its endocytosis, its intracellular routing and the pathogenetic mechanisms of the cell damage, are reported.
Journal ArticleDOI
Xanthine oxidoreductase in cancer: more than a differentiation marker
TL;DR: The role of uric acid is characterized by both oxidant and antioxidant action; thus, it is still debatable whether control of uriemia may be helpful to improve the outcomes of tumor illness.
Journal ArticleDOI
Ricin: An Ancient Story for a Timeless Plant Toxin.
TL;DR: This manuscript intends to give the reader an overview of ricin, focusing on the historical path to the current knowledge on this protein, with particular regard to its enzymatic activity, structure, and cytotoxicity.