M
Massimo Micaroni
Researcher at University of Queensland
Publications - 32
Citations - 3711
Massimo Micaroni is an academic researcher from University of Queensland. The author has contributed to research in topics: Golgi apparatus & Secretory pathway. The author has an hindex of 21, co-authored 32 publications receiving 3238 citations. Previous affiliations of Massimo Micaroni include University of Exeter & University of Gothenburg.
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Journal ArticleDOI
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza,Sara Cipolat,Olga Martins de Brito,Massimo Micaroni,Galina V. Beznoussenko,Tomasz Rudka,Davide Bartoli,Roman S. Polishuck,Nika N. Danial,Bart De Strooper,Luca Scorrano +10 more
TL;DR: Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.
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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
Christian Frezza,Liang Zheng,Ori Folger,Kartik N. Rajagopalan,Elaine D. MacKenzie,Livnat Jerby,Massimo Micaroni,Barbara Chaneton,Julie Adam,Ann Hedley,Gabriela Kalna,Ian Tomlinson,Patrick J. Pollard,Dave Watson,Ralph J. DeBerardinis,Tomer Shlomi,Eytan Ruppin,Eyal Gottlieb +17 more
TL;DR: This work predicted and confirmed that targeting this pathway would render Fh1-deficient cells non-viable, while sparing wild-type Fh2-containing cells, and demonstrated that inhibition of haem oxygenation is synthetically lethal when combined with Fh 1 deficiency.
Journal ArticleDOI
Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin
Genny Orso,Diana Pendin,Song Liu,Jessica Tosetto,Tyler J. Moss,Joseph E. Faust,Massimo Micaroni,Anastasia Egorova,Andrea Martinuzzi,James A. McNew,Andrea Daga +10 more
TL;DR: It is demonstrated that Atlastin mediates membrane tethering and fusion and strongly suggest that it is the GTPase activity that is required for ER homotypic fusion, which is shown to depend on GTP hydrolysis.
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Mitochondria Are Linked to Calcium Stores in Striated Muscle by Developmentally Regulated Tethering Structures
Simona Boncompagni,Ann E. Rossi,Massimo Micaroni,Galina V. Beznoussenko,Roman S. Polishchuk,Robert T. Dirksen,Feliciano Protasi +6 more
TL;DR: T tethers are suggested to establish and maintain SR-mitochondrial association during postnatal maturation and in adult muscle and likely provide a structural framework for bi-directional signaling between the two organelles in striated muscle.
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Selenite biotransformation and detoxification by Stenotrophomonas maltophilia SeITE02: Novel clues on the route to bacterial biogenesis of selenium nanoparticles.
Silvia Lampis,Emanuele Zonaro,Cristina Bertolini,Daniela Cecconi,Francesca Monti,Massimo Micaroni,Raymond J. Turner,Clive S. Butler,Giovanni Vallini +8 more
TL;DR: A putative biosynthetic mechanism for selenium nanoparticles (SeNPs) and efficient reduction of selenite (SeO32-) in the bacterial strain Stenotrophomonas maltophilia SeITE02 are addressed here on the basis of information gained by a combined approach relying on a set of physiological, chemical/biochemical, microscopy, and proteomic analyses.