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Mathias Basner

Bio: Mathias Basner is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Noise & Sleep deprivation. The author has an hindex of 41, co-authored 183 publications receiving 8052 citations. Previous affiliations of Mathias Basner include Harvard University & German Aerospace Center.


Papers
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Journal ArticleDOI
TL;DR: It is unlikely that the proposed curfew at Frankfurt Airport substantially benefits sleep structure, and models indicate small improvements in sleep structure in nights with curfew, even if all traffic is rescheduled to periods before and after the curfew period.
Abstract: Background. Aircraft noise disturbs sleep and impairs recuperation. Authorities plan to expand Frankfurt airport. Objective. To quantitatively assess the effects of a traffic curfew (11 PM to 5 AM) at Frankfurt Airport on sleep structure. Design. Experimental sleep study; polysomnography for 13 consecutive nights. Setting. Sleep laboratory. Subjects. 128 healthy subjects, mean age (SD) 38 (13) years, range 19 to 65, 59% female. Intervention. Exposure to aircraft noise via loudspeakers. Measurements. A 6-state Markov state transition sleep model was used to simulate 3 noise scenarios with first-order Monte Carlo simulations: 1) 2005 traffic at Frankfurt Airport, 2) as simulation 1 but flights between 11 PM and 5 AM cancelled, and 3) as simulation 2, with flights between 11 PM and 5 AM from simulation 1 rescheduled to periods before 11 PM and after 5 AM. Probabilities for transitions between sleep stages were estimated with autoregressive multinomial logistic regression. Results. Compared to a night without...

7 citations

Mathias Basner1, H. Buess, Uwe Müller, G. Plath, A. Samel 
01 Jan 2004
TL;DR: The combination of a huge database and new statistical procedures allows the precise prediction of the influence of nocturnal aircraft noise on sleep, which again can be used for the proposal of advanced rules for the protection of residents living near airports.
Abstract: 500] OBJECTIVES Sleep is vital for the recovery of physical and mental capacities. Environmental noise is a potential disrupter of the sleep process. In order to develop scientifically sound criteria for the operation and restriction of nocturnal air traffic, the DLR-Institute of Aerospace Medicine investigated the influence of nocturnal aircraft noise on sleep, mood and behavior in four representative laboratory and two field studies between 1999 and 2003. METHODS In the lab, 128 subjects aged 18-65 were investigated during 13 consecutive nights (total: 1,664 nights). Between 4 and 128 aircraft noise events with LAS,max between 45 and 80 dB(A) were played back between 11 p.m. and 7 a.m. Results were compared to the findings of two field studies with 64 subjects and 576 nights in total. Here, sound pressure levels were simultaneously measured indoors and outdoors. Electrophysiological signals included polysomnography, EKG, plethysmography, respiration and actigraphy. Synchronous recording with acoustic data assured event related analysis. RESULTS Random effects logistic regression was used for the prediction of noise induced awakenings depending on LAS,max and the calculation of dose–response curves. A comparison of the awakening probability between lab and field revealed striking differences. Based on these results, new criteria for the restriction of nocturnal air traffic were developed and will be presented. CONCLUSIONS The combination of a huge database and new statistical procedures allows the precise prediction of the influence of nocturnal aircraft noise on sleep, which again can be used for the proposal of advanced rules for the protection of residents living near airports.

7 citations

01 Jul 2008
TL;DR: In this paper, the effects of a nocturnal air traffic curfew at Frankfurt Airport on sleep structure were quantitatively assessed using an autoregressive multinomial logistic regression model.
Abstract: OBJECTIVES: To quantitatively assess the effects of the introduction of a nocturnal air traffic curfew at Frankfurt Airport on sleep structure. METHODS: A six state (Wake, S1, S2, S3, S4 and REM) Markov state transition sleep model was built. Transition probabilities between states were calculated with autoregressive multinomial logistic regression based on polysomnographic laboratory study data. Monte Carlo simulation trials were performed for modelling a noise-free night and three noise scenarios: (1) traffic at Frankfurt Airport on 16 August 2005, (2) as (1), but flights between 11 pm and 5 am cancelled and (3) as (2), with flights between 11 pm and 5 am from (1) rescheduled to periods before 11 pm and after 5 am. RESULTS: The results indicate that there will be a small benefit for airport residents compared to the current situation even if all traffic is rescheduled (average time spent awake -3.2 %, S1 -4.6 %, S2 -0.9 %, S3 +3 %, S4 +9.2 %, REM +0.6 %, number of sleep stage changes -2.5 %). This benefit is likely to be outweighed by the increase in air traffic during shoulder hours, especially for those who choose to or have to go to bed before 10:30 pm or after 1 am. CONCLUSIONS: Alternative strategies might be necessary to both guarantee undisturbed sleep of airport residents and to minimize economic and legal disadvantages accompanied by a traffic curfew. The models developed in this investigation may serve as a valuable tool for optimizing air traffic patterns at airports, and therefore guide political decision making.

7 citations

Journal ArticleDOI
TL;DR: The posterior dominant rhythm (PDR) was the first oscillatory pattern noted in the EEG and has been investigated for tracking cognitive dysfunction after anaesthetic-induced loss of consciousness as mentioned in this paper .
Abstract: The posterior dominant rhythm (PDR) was the first oscillatory pattern noted in the EEG. Evoked by wakeful eyelid closure, these oscillations dissipate over seconds during loss of arousal. The peak frequency of the PDR maintains stability over years, suggesting utility as a state biomarker in the surveillance of acute cognitive impairments. This EEG signature has not been systematically investigated for tracking cognitive dysfunction after anaesthetic-induced loss of consciousness.This substudy of Reconstructing Consciousness and Cognition (NCT01911195) investigated the PDR and cognitive function in 60 adult volunteers randomised to either 3 h of isoflurane general anaesthesia or resting wakefulness. Serial measurements of EEG power and cognitive task performance were assessed relative to pre-intervention baseline. Mixed-effects models allowed quantification of PDR and neurocognitive trajectories after return of responsiveness (ROR).Individuals in the control group showed stability in the PDR peak frequency over several hours (median difference/inter-quartile range [IQR] of 0.02/0.20 Hz, P=0.39). After isoflurane general anaesthesia, the PDR peak frequency was initially reduced at ROR (median difference/IQR of 0.88/0.65 Hz, P<0.001). PDR peak frequency recovered at a rate of 0.20 Hz h-1. After ROR, the PDR peak frequency correlated with reaction time and accuracy on multiple cognitive tasks (P<0.001).The temporal trajectory of the PDR peak frequency could be a useful perioperative marker for tracking cognitive dysfunction on the order of hours after surgery, particularly for cognitive domains of working memory, visuomotor speed, and executive function.NCT01911195.

7 citations


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Book ChapterDOI
01 Jan 2010

5,842 citations

Journal ArticleDOI
TL;DR: It is concluded that multiple Imputation for Nonresponse in Surveys should be considered as a legitimate method for answering the question of why people do not respond to survey questions.
Abstract: 25. Multiple Imputation for Nonresponse in Surveys. By D. B. Rubin. ISBN 0 471 08705 X. Wiley, Chichester, 1987. 258 pp. £30.25.

3,216 citations

Journal ArticleDOI
Tamar Frankel1
TL;DR: The Essay concludes that practitioners theorize, and theorists practice, use these intellectual tools differently because the goals and orientations of theorists and practitioners, and the constraints under which they act, differ.
Abstract: Much has been written about theory and practice in the law, and the tension between practitioners and theorists. Judges do not cite theoretical articles often; they rarely "apply" theories to particular cases. These arguments are not revisited. Instead the Essay explores the working and interaction of theory and practice, practitioners and theorists. The Essay starts with a story about solving a legal issue using our intellectual tools - theory, practice, and their progenies: experience and "gut." Next the Essay elaborates on the nature of theory, practice, experience and "gut." The third part of the Essay discusses theories that are helpful to practitioners and those that are less helpful. The Essay concludes that practitioners theorize, and theorists practice. They use these intellectual tools differently because the goals and orientations of theorists and practitioners, and the constraints under which they act, differ. Theory, practice, experience and "gut" help us think, remember, decide and create. They complement each other like the two sides of the same coin: distinct but inseparable.

2,077 citations

Journal Article
TL;DR: Definition: To what extent does the study allow us to draw conclusions about a causal effect between two or more constructs?
Abstract: Definition: To what extent does the study allow us to draw conclusions about a causal effect between two or more constructs? Issues: Selection, maturation, history, mortality, testing, regression towrd the mean, selection by maturation, treatment by mortality, treatment by testing, measured treatment variables Increase: Eliminate the threats, above all do experimental manipulations, random assignment, and counterbalancing.

2,006 citations