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Mathias Basner

Bio: Mathias Basner is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Noise & Sleep deprivation. The author has an hindex of 41, co-authored 183 publications receiving 8052 citations. Previous affiliations of Mathias Basner include Harvard University & German Aerospace Center.


Papers
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Journal ArticleDOI
TL;DR: Current research suggests dynamic differences in the way the central nervous system responds to acute versus chronic sleep restriction, which is reflected in new models of sleep-wake regulation.

142 citations

Journal ArticleDOI
TL;DR: A high-fidelity ground simulation of a Mars mission was used to objectively track sleep–wake dynamics in a multinational crew of six during 520 d of confined isolation, revealing that crew sedentariness increased across the mission as evident in decreased waking movement and increased sleep and rest times.
Abstract: The success of interplanetary human spaceflight will depend on many factors, including the behavioral activity levels, sleep, and circadian timing of crews exposed to prolonged microgravity and confinement. To address the effects of the latter, we used a high-fidelity ground simulation of a Mars mission to objectively track sleep–wake dynamics in a multinational crew of six during 520 d of confined isolation. Measurements included continuous recordings of wrist actigraphy and light exposure (4.396 million min) and weekly computer-based neurobehavioral assessments (n = 888) to identify changes in the crew's activity levels, sleep quantity and quality, sleep–wake periodicity, vigilance performance, and workload throughout the record-long 17 mo of mission confinement. Actigraphy revealed that crew sedentariness increased across the mission as evident in decreased waking movement (i.e., hypokinesis) and increased sleep and rest times. Light exposure decreased during the mission. The majority of crewmembers also experienced one or more disturbances of sleep quality, vigilance deficits, or altered sleep–wake periodicity and timing, suggesting inadequate circadian entrainment. The results point to the need to identify markers of differential vulnerability to hypokinesis and sleep–wake changes during the prolonged isolation of exploration spaceflight and the need to ensure maintenance of circadian entrainment, sleep quantity and quality, and optimal activity levels during exploration missions. Therefore, successful adaptation to such missions will require crew to transit in spacecraft and live in surface habitats that instantiate aspects of Earth's geophysical signals (appropriately timed light exposure, food intake, exercise) required for temporal organization and maintenance of human behavior.

138 citations

Journal ArticleDOI
TL;DR: This research corroborated findings that noise events induce arousals at relatively low exposure levels, and independent of the noise source and the environment and suggested that nocturnal noise exposure may be more relevant for the genesis of cardiovascular disease than daytime noise exposure.
Abstract: This paper summarizes the findings from the past 3 year's research on the effects of environmental noise on sleep and identifies key future research goals. The past 3 years have seen continued interest in both short term effects of noise on sleep (arousals, awakenings), as well as epidemiological studies focusing on long term health impacts of nocturnal noise exposure. This research corroborated findings that noise events induce arousals at relatively low exposure levels, and independent of the noise source (air, road, and rail traffic, neighbors, church bells) and the environment (home, laboratory, hospital). New epidemiological studies support already existing evidence that night-time noise is likely associated with cardiovascular disease and stroke in the elderly. These studies collectively also suggest that nocturnal noise exposure may be more relevant for the genesis of cardiovascular disease than daytime noise exposure. Relative to noise policy, new effect-oriented noise protection concepts, and rating methods based on limiting awakening reactions were introduced. The publications of WHO's ''Night Noise Guidelines for Europe'' and ''Burden of Disease from Environmental Noise'' both stress the importance of nocturnal noise exposure for health and well-being. However, studies demonstrating a causal pathway that directly link noise (at ecological levels) and disturbed sleep with cardiovascular disease and/or other long term health outcomes are still missing. These studies, as well as the quantification of the impact of emerging noise sources (e.g., high speed rail, wind turbines) have been identified as the most relevant issues that should be addressed in the field on the effects of noise on sleep in the near future.

132 citations

Journal ArticleDOI
25 Nov 2020-Cell
TL;DR: The known hazards of human spaceflight are reviewed, how spaceflight affects living systems through these six fundamental features, and the associated health risks of space exploration are discussed.

131 citations

Journal ArticleDOI
01 Apr 2008-Sleep
TL;DR: Cardiac responses did not habituate to traffic noise within the night and may therefore play a key role in promoting traffic noise induced cardiovascular disease, more likely for responses accompanied by awakenings than for situations without awakenings.
Abstract: TRANSIENT EXCITATIONS OF THE CENTRAL AND OF THE AUTONOMIC NERVOUS SYSTEM WITH A COMMON ORIGIN IN THE BRAINSTEM OCCUR FREQUENTLY and spontaneously (with no obvious reason) during normal sleep. Cortical arousals, which might lead to sleep stage changes or awakenings, are usually accompanied by autonomic arousals. As the reverse is not true, the latter may occur alone.1,2 Autonomic arousals are transient elevations of the sympathetic tone. They encompass increases of ventilation, of systolic and diastolic blood pressure, and of peripheral resistance; but they but are most often indicated by alterations of heart rate (HR). These cardiac arousals start to increase well before the visually detectable onset of cortical arousals.1–3 Their extent and patterns vary with the duration of the cortical arousals. With cortical arousals lasting up to 10 s, cardiac arousals are typically biphasic: an initial acceleration is followed by a deceleration below the baseline. The baseline is then regained after a gradual increase 15–30 s after stimulus onset.1,3–5 With longer lasting arousals the deceleration becomes gradually flatter, thus leading to a monophasic elevation of heart rate.1,4–5 Similar alterations are evoked by various external stimuli, in particular by acoustic stimuli.6–8 Research in this area was usually performed with artificial sounds, mostly with tones of up to 4 kHz and durations up to 5 s.6–12 The extents and the patterns of these responses were analyzed in detail and were shown to depend at least on stimulus intensity and on the sleep stage at the time of stimulation. Traffic noises are a major cause of extrinsic sleep disturbances with after effects on mood, performance, and health.13 Despite this, cardiac responses to traffic noise have only occasionally been studied.14–17 A detailed analysis of these responses was performed only for sonic booms, which evoked the typical biphasic cardiac arousals described above.18 This paper deals with the cardiac responses of 24 persons to noises from aircraft, rail, and road vehicles during sleep in the laboratory. It investigates possible influences of acoustical parameters, time of night and momentary sleep stage. Such an analysis is highly relevant as numerous residents living in the vicinity of airports, along busy streets, and along railway tracks are permanently exposed to these noises while sleeping. Long-term exposure to these noises is assumed to contribute to the genesis of cardiovascular diseases.19

122 citations


Cited by
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Book ChapterDOI
01 Jan 2010

5,842 citations

Journal ArticleDOI
TL;DR: It is concluded that multiple Imputation for Nonresponse in Surveys should be considered as a legitimate method for answering the question of why people do not respond to survey questions.
Abstract: 25. Multiple Imputation for Nonresponse in Surveys. By D. B. Rubin. ISBN 0 471 08705 X. Wiley, Chichester, 1987. 258 pp. £30.25.

3,216 citations

Journal ArticleDOI
Tamar Frankel1
TL;DR: The Essay concludes that practitioners theorize, and theorists practice, use these intellectual tools differently because the goals and orientations of theorists and practitioners, and the constraints under which they act, differ.
Abstract: Much has been written about theory and practice in the law, and the tension between practitioners and theorists. Judges do not cite theoretical articles often; they rarely "apply" theories to particular cases. These arguments are not revisited. Instead the Essay explores the working and interaction of theory and practice, practitioners and theorists. The Essay starts with a story about solving a legal issue using our intellectual tools - theory, practice, and their progenies: experience and "gut." Next the Essay elaborates on the nature of theory, practice, experience and "gut." The third part of the Essay discusses theories that are helpful to practitioners and those that are less helpful. The Essay concludes that practitioners theorize, and theorists practice. They use these intellectual tools differently because the goals and orientations of theorists and practitioners, and the constraints under which they act, differ. Theory, practice, experience and "gut" help us think, remember, decide and create. They complement each other like the two sides of the same coin: distinct but inseparable.

2,077 citations

Journal Article
TL;DR: Definition: To what extent does the study allow us to draw conclusions about a causal effect between two or more constructs?
Abstract: Definition: To what extent does the study allow us to draw conclusions about a causal effect between two or more constructs? Issues: Selection, maturation, history, mortality, testing, regression towrd the mean, selection by maturation, treatment by mortality, treatment by testing, measured treatment variables Increase: Eliminate the threats, above all do experimental manipulations, random assignment, and counterbalancing.

2,006 citations