Mathias Basner

Bio: Mathias Basner is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Noise & Sleep deprivation. The author has an hindex of 41, co-authored 183 publications receiving 8052 citations. Previous affiliations of Mathias Basner include Harvard University & German Aerospace Center.

Sleep duration in the United States 2003-2016: first signs of success in the fight against sleep deficiency?

Abstract: Study Objectives The high prevalence of chronic insufficient sleep in the population has been a concern due to the associated health and safety risks. We evaluated secular trends in sleep duration over the most recent 14-year period. Methods The American Time Use Survey, representative of US residents ≥15 years, was used to investigate trends in self-reported sleep duration and waking activities for the period 2003-2016 (N = 181335 respondents). Results Sleep duration increased across survey years both on weekdays (+1.40 min/year) and weekends (+0.83 min/year, both p 7-9 hr), and long (>9 hr) sleep changed by -0.44% per year (p < .0001), -0.03% per year (p = .5515), and +0.48% per year (p < .0001), respectively. The change in sleep duration was predominantly explained by respondents retiring earlier in the evening. The percentage of respondents who watched TV or read before bed-two prominent waking activities competing with sleep-decreased over the same time period, suggesting that portions of the population are increasingly willing to trade time in leisure activities for more sleep. The results also suggest that increasing online opportunities to work, learn, bank, shop, and perform administrative tasks from home freed up time that likely contributed to increased sleep duration. Conclusions The findings indicate first successes in the fight against sleep deficiency. Public health consequences of the observed increase in the prevalence of long sleep remain unclear and warrant further investigation.

Event-related awakenings caused by nocturnal transportation noise.

Abstract: The present study focussed on awakenings caused by nocturnal noises emitted from aircraft, road and rail vehicles with maximum levels ranging from 40 to 76 dBA. A laboratory study with 24 participants (12 male, 12 female, 19-28 years) was performed with polysomnographic recordings during 13 nights (including a preceding habituation night). Multivariable random subject effect logistic regression models containing acoustical, situational and individual parameters were used to determine the probability of event-related awakenings for each traffic mode. Awakening probability increased significantly with maximum sound pressure level (SPL), slope of rise (dB/s), noise duration and the noise-free interval between noise events. Gender, noise sensitivity and age did not influence awakening probability significantly (the latter only in a combined model). Awakening probability increased with elapsed time after sleep onset, and was significantly lower during slow wave sleep compared to S2 sleep, but not during REM sleep. After adjusting for differences in study design (acoustical macrostructure), awakening probability decreased in the order rail, road and air traffic noise, but only rail and air traffic noise differed significantly (p= 0.002). After further adjusting for slope of rise and noise duration (acoustical microstructure), differences between traffic modes decreased, but rail and air traffic noise still differed significantly (p=0.044). Acoustical properties other than slope of rise and noise duration may account for the residual difference. The results of this study suggest that the reduction of maximum SPLs, rise slopes, and traffic volume during the second part of the night might reduce the number of noise-induced awakenings.

An ECG-based Algorithm for the Automatic Identification of Autonomic Activations Associated with Cortical Arousal

Abstract: Objectives: EEG arousals are associated with autonomic activations. Visual EEG arousal scoring is time consuming and suffers from low interob-server agreement. We hypothesized that information on changes in heart rate alone suffice to predict the occurrence of cortical arousal. Methods: Two visual AASM EEG arousal scorings of 56 healthy subject nights (mean age 37.0 ± 12.8 years, 26 male) were obtained. For each of 5 heartbeats following the onset of 3581 consensus EEG arousals and of an equal number of control conditions, differences to a moving median were calculated and used to estimate likelihood ratios (LRs) for 10 categories of heartbeat differences. Comparable to 5 consecutive diagnostic tests, these LRs were used to calculate the probability of heart rate responses being associated with cortical arousals. Results: EEG and ECG arousal indexes agreed well across a wide range of decision thresholds, resulting in a receiver operating characteristic (ROC) with an area under the curve of 0.91. For the decision threshold chosen for the final analyses, a sensitivity of 68.1% and a specificity of 95.2% were obtained. ECG and EEG arousal indexes were poorly correlated (r = 0.19, P <0.001, ICC = 0.186), which could in part be attributed to 3 outliers. The Bland-Altman plot showed an unbiased estimation of EEG arousal indexes by ECG arousal indexes with a standard deviation of ± 7.9 arousals per hour sleep. In about two-thirds of all cases, ECG arousal scoring was matched by at least one (22.2%) or by both (42.5%) of the visual scorings. Sensitivity of the algorithm increased with increasing duration of EEG arousals. The ECG algorithm was also successfully validated with 30 different nights of 10 subjects (mean age 35.3 □ 13.6 years, 5 male). Conclusions: In its current version, the ECG algorithm cannot replace visual EEG arousal scoring. Sensitivity for detecting <10-s EEG arousals needs to be improved. However, in a nonclinical population, it may be valuable to supplement visual EEG arousal scoring by this automatic, objective, reproducible, cheap, and time-saving method.

Patient Safety Outcomes under Flexible and Standard Resident Duty-Hour Rules

Abstract: Background Concern persists that extended shifts in medical residency programs may adversely affect patient safety. Methods We conducted a cluster-randomized noninferiority trial in 63 int...

Aircraft noise effects on sleep: Mechanisms, mitigation and research needs

Abstract: There is an ample number of laboratory and field studies which provide sufficient evidence that aircraft noise disturbs sleep and, depending on traffic volume and noise levels, may impair behavior and well-being during the day. Although clinical sleep disorders have been shown to be associated with increased risk of cardiovascular diseases, only little is known about the long-term effects of aircraft noise disturbed sleep on health. National and international laws and guidelines try to limit aircraft noise exposure facilitating active and passive noise control to prevent relevant sleep disturbances and its consequences. Adopting the harmonized indicator of the European Union Directive 2002/49/EC, the WHO Night Noise Guideline for Europe (NNG) defines four Lnight , outside ranges associated with different risk levels of sleep disturbance and other health effects ( 55 dBA). Although traffic patterns differing in number and noise levels of events that lead to varying degrees of sleep disturbance may result in the same Lnight , simulations of nights with up to 200 aircraft noise events per night nicely corroborate expert opinion guidelines formulated in WHO's NNG. In the future, large scale field studies on the effects of nocturnal (aircraft) noise on sleep are needed. They should involve representative samples of the population including vulnerable groups like children and chronically ill subjects. Optimally, these studies are prospective in nature and examine the long-term consequences of noise-induced sleep disturbances. Furthermore, epidemiological case-control studies on the association of nocturnal (aircraft) noise exposure and cardiovascular disease are needed. Despite the existing gaps in knowledge on long-term health effects, sufficient data are available for defining limit values, guidelines and protection concepts, which should be updated with the availability of new data.

Multiple Imputation for Nonresponse in Surveys

Abstract: 25. Multiple Imputation for Nonresponse in Surveys. By D. B. Rubin. ISBN 0 471 08705 X. Wiley, Chichester, 1987. 258 pp. £30.25.

Of Theory and Practice

Abstract: Much has been written about theory and practice in the law, and the tension between practitioners and theorists. Judges do not cite theoretical articles often; they rarely "apply" theories to particular cases. These arguments are not revisited. Instead the Essay explores the working and interaction of theory and practice, practitioners and theorists. The Essay starts with a story about solving a legal issue using our intellectual tools - theory, practice, and their progenies: experience and "gut." Next the Essay elaborates on the nature of theory, practice, experience and "gut." The third part of the Essay discusses theories that are helpful to practitioners and those that are less helpful. The Essay concludes that practitioners theorize, and theorists practice. They use these intellectual tools differently because the goals and orientations of theorists and practitioners, and the constraints under which they act, differ. Theory, practice, experience and "gut" help us think, remember, decide and create. They complement each other like the two sides of the same coin: distinct but inseparable.

Reliability and validity

Abstract: Definition: To what extent does the study allow us to draw conclusions about a causal effect between two or more constructs? Issues: Selection, maturation, history, mortality, testing, regression towrd the mean, selection by maturation, treatment by mortality, treatment by testing, measured treatment variables Increase: Eliminate the threats, above all do experimental manipulations, random assignment, and counterbalancing.