Mathis O. Riehle

Bio: Mathis O. Riehle is an academic researcher from University of Glasgow. The author has contributed to research in topics: Nanotopography & Tissue engineering. The author has an hindex of 46, co-authored 143 publications receiving 10338 citations. Previous affiliations of Mathis O. Riehle include University of Strathclyde & University of Southampton.

The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder

Abstract: A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without compromising material properties. At present, conventional implant materials fail owing to encapsulation by soft tissue, rather than direct bone bonding. Here, we demonstrate the use of nanoscale disorder to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements. This approach has similar efficiency to that of cells cultured with osteogenic media. In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies.

Superhydrophobicity and Superhydrophilicity of Regular Nanopatterns

Abstract: The hydrophilicity, hydrophobicity, and sliding behaviour of water droplets on nanoasperities of controlled dimensions were investigated experimentally. We show that the "hemi-wicking"theory for hydrophilic SiO2 samples successfully predicts the experimental advancing angles and that the same patterns, after silanization, become superhydrophobic in agreement with the Cassie-Baxter and Wenzel theories. Our model tophographies have the same dimensional scale of some naturally occurring structures that exhibit similar wetting properties. Our results confirm that a forest of hydrophilic/hydrophobic slender pillars is the most effective superwettable/water-repellent configuration. It is shown that the shape and curvature of the edges of the aspertieis play an important role in determining the advancing angles.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

“Bioinformatics” 특집을 내면서

Abstract: BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

Bioinspired self-repairing slippery surfaces with pressure-stable omniphobicity

Abstract: Inspired by the insect-eating Nepenthes pitcher plant, which snares its prey on a surface lubricated by a remarkably slippery aqueous secretion, Joanna Aizenberg and colleagues have synthesized omniphobic surfaces that can self-repair and function at high pressures. Their 'slippery liquid-infused porous surfaces' (or SLIPS) exhibit almost perfect slipperiness towards polar, organic and complex liquids. SLIPS function under extreme conditions, are easily constructed from inexpensive materials and can be endowed with other useful characteristics, such as enhanced optical transparency, through the selection of appropriate substrates and lubricants. Ultra-slippery surfaces of this type might find application in biomedical fluid handling, fuel transport, antifouling, anti-icing, optical imaging and elsewhere. Creating a robust synthetic surface that repels various liquids would have broad technological implications for areas ranging from biomedical devices and fuel transport to architecture but has proved extremely challenging1. Inspirations from natural nonwetting structures2,3,4,5,6, particularly the leaves of the lotus, have led to the development of liquid-repellent microtextured surfaces that rely on the formation of a stable air–liquid interface7,8,9. Despite over a decade of intense research, these surfaces are, however, still plagued with problems that restrict their practical applications: limited oleophobicity with high contact angle hysteresis9, failure under pressure10,11,12 and upon physical damage1,7,11, inability to self-heal and high production cost1,11. To address these challenges, here we report a strategy to create self-healing, slippery liquid-infused porous surface(s) (SLIPS) with exceptional liquid- and ice-repellency, pressure stability and enhanced optical transparency. Our approach—inspired by Nepenthes pitcher plants13—is conceptually different from the lotus effect, because we use nano/microstructured substrates to lock in place the infused lubricating fluid. We define the requirements for which the lubricant forms a stable, defect-free and inert ‘slippery’ interface. This surface outperforms its natural counterparts2,3,4,5,6 and state-of-the-art synthetic liquid-repellent surfaces8,9,14,15,16 in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low contact angle hysteresis (<2.5°), quickly restore liquid-repellency after physical damage (within 0.1–1 s), resist ice adhesion, and function at high pressures (up to about 680 atm). We show that these properties are insensitive to the precise geometry of the underlying substrate, making our approach applicable to various inexpensive, low-surface-energy structured materials (such as porous Teflon membrane). We envision that these slippery surfaces will be useful in fluid handling and transportation, optical sensing, medicine, and as self-cleaning and anti-fouling materials operating in extreme environments.