M
Matt Kaeberlein
Researcher at University of Washington
Publications - 292
Citations - 28274
Matt Kaeberlein is an academic researcher from University of Washington. The author has contributed to research in topics: Longevity & Saccharomyces cerevisiae. The author has an hindex of 68, co-authored 264 publications receiving 25231 citations. Previous affiliations of Matt Kaeberlein include Western Washington University & Guangdong Medical College.
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
TL;DR: The analysis of two SIR2 mutations supports the idea that this deacetylase activity accounts for silencing, recombination suppression and extension of life span in vivo, and provides a molecular framework of NAD-dependent histone de acetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes.
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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
TL;DR: It is shown that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining, and increasing the gene dosage extends the life span in wild-type cells.
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mTOR is a key modulator of ageing and age-related disease
TL;DR: Although adverse side effects currently preclude use in otherwise healthy individuals, drugs that target the mTOR pathway could one day become widely used to slow ageing and reduce age-related pathologies in humans.
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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Matt Kaeberlein,R. Wilson Powers,Kristan K. Steffen,Eric A. Westman,Di Hu,Nick Dang,Emily O. Kerr,Kathryn T. Kirkland,Stanley Fields,Brian K. Kennedy +9 more
TL;DR: It is proposed that the TOR and Sch9 kinases define a primary conduit through which excess nutrient intake limits longevity in yeast.
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Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Su Ju Lin,Matt Kaeberlein,Alex A. Andalis,Lori A. Sturtz,Pierre-Antoine Defossez,Pierre-Antoine Defossez,Valeria C. Culotta,Gerald R. Fink,Leonard Guarente +8 more
TL;DR: In this paper, a model of calorie restriction in yeast Saccharomyces cerevisiae was established and it was shown that the shunting of carbon metabolism toward the mitochondrial tricarboxylic acid cycle and the concomitant increase in respiration play a central part in this process.