Matteo Cocuzza

Bio: Matteo Cocuzza is an academic researcher from Polytechnic University of Turin. The author has contributed to research in topics: PEDOT:PSS & Graphene. The author has an hindex of 21, co-authored 106 publications receiving 1435 citations. Previous affiliations of Matteo Cocuzza include National Research Council & Istituto Italiano di Tecnologia.

PDMS membranes with tunable gas permeability for microfluidic applications

Abstract: The air permeability of PDMS membranes is easily tuned by varying their composition. By varying the mixing ratio between oligomers and curing agent it is possible to strongly influence the chemical and mechanical properties of the elastomer resulting in a huge increase in the permeation of gas molecules across the membrane.

Silicon resonant microcantilevers for absolute pressure measurement

Abstract: This work is focused on the developing of silicon resonant microcantilevers for the measurement of the absolute pressure. The microcantilevers have been fabricated with a two-mask bulk micromachining process. The variation in resonance response of microcantilevers was investigated as a function of pressure (10−1–105Pa), both in terms of resonance frequency and quality factor. A theoretical description of the resonating microstructure is given according to different molecular and viscous regimes. Also a brief discussion on the different quality factors contributions is presented. Theoretical and experimental data show a very satisfying agreement. The microstructure behavior demonstrates a certain sensitivity over a six decade range and the potential evolution of an absolute pressure sensor working in the same range.

High-Performing and Stable Wearable Supercapacitor Exploiting rGO Aerogel Decorated with Copper and Molybdenum Sulfides on Carbon Fibers

Abstract: Herein the concomitant synthesis of a MoS2- and Cu7S4-decorated graphene aerogel is reported. The material is fully characterized and used as an active material to coat carbon fiber electrodes for the fabrication of a fiber-shaped supercapacitor. The device provides excellent capacitance values warranting stable performance even under high bending angle conditions. Moreover, a photocurable resin is selected as a smart packaging material to overcome stability problems usually affecting this class of devices. It is noteworthy that superior stability is demonstrated with a retention of almost 80% of the initial capacitance after one month. Flexible supercapacitors were also coupled with third-generation solar cells to successfully demonstrate the fabrication of wearable, portable, and integrated smart energy devices.

Integration of organic electrochemical transistors and immuno-affinity membranes for label-free detection of interleukin-6 in the physiological concentration range through antibody-antigen recognition.

Abstract: We demonstrate the label-free and selective detection of interleukin-6 (IL-6), a key cell-signaling molecule in biology and medicine, by integrating an OECT with an immuno-affinity regenerated cellulose membrane. The objective of the membrane is to increase the local concentration of IL-6 at the sensing electrode and, thereby, enhance the device response for concentrations falling within the physiological concentration range of cytokines. The OECT gate electrode is functionalized with an oligo(ethylene glycol)-terminated self-assembled alkanethiolate monolayer (SAM) for both the immobilization of anti IL-6 antibodies and the inhibition of non-specific biomolecule binding. The OECT gate/electrolyte interface is exploited for the selective detection of IL-6 through the monitoring of antigen–antibody binding events occurring at the gate electrode.

Handbook of Chemistry and Physics

Abstract: There is a special reason for reviewing this book at this time: it is the 50th edition of a compendium that is known and used frequently in most chemical and physical laboratories in many parts of the world. Surely, a publication that has been published for 56 years, withstanding the vagaries of science in this century, must have had something to offer. There is another reason: while the book is a standard fixture in most chemical and physical laboratories, including those in medical centers, it is not as frequently seen in the laboratories of physician's offices (those either in solo or group practice). I believe that the Handbook can be useful in those laboratories. One of the reasons, among others, is that the various basic items of information it offers may be helpful in new tests, either physical or chemical, which are continuously being published. The basic information may relate

Liposomes as nanomedical devices

Abstract: Since their discovery in the 1960s, liposomes have been studied in depth, and they continue to constitute a field of intense research. Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier system known to date. Notable progress has been made, and several biomedical applications of liposomes are either in clinical trials, are about to be put on the market, or have already been approved for public use. In this review, we briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization. Moreover, we discuss the influence of the physicochemical properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. Finally, we describe some strategies developed to overcome limitations of the "first-generation" liposomes, and liposome-based drugs on the market and in clinical trials.

Microfluidic Mixing: A Review

Abstract: The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly speaking, microfluidic mixing schemes can be categorized as either “active”, where an external energy force is applied to perturb the sample species, or “passive”, where the contact area and contact time of the species samples are increased through specially-designed microchannel configurations. Many mixers have been proposed to facilitate this task over the past 10 years. Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers.