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Matteo Pastorino

Bio: Matteo Pastorino is an academic researcher from Technical University of Madrid. The author has contributed to research in topics: Microwave imaging & Inverse scattering problem. The author has an hindex of 21, co-authored 91 publications receiving 1371 citations. Previous affiliations of Matteo Pastorino include Complutense University of Madrid.


Papers
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Journal ArticleDOI
11 Nov 2014-Sensors
TL;DR: The PERFORM system is an intelligent closed-loop system that seamlessly integrates a wide range of wearable sensors constantly monitoring several motor signals of Parkinson's disease patients to offer to the clinician a precise, long-term and objective view of patient's motor status and drug/food intake.
Abstract: In this paper, we describe the PERFORM system for the continuous remote monitoring and management of Parkinson's disease (PD) patients. The PERFORM system is an intelligent closed-loop system that seamlessly integrates a wide range of wearable sensors constantly monitoring several motor signals of the PD patients. Data acquired are pre-processed by advanced knowledge processing methods, integrated by fusion algorithms to allow health professionals to remotely monitor the overall status of the patients, adjust medication schedules and personalize treatment. The information collected by the sensors (accelerometers and gyroscopes) is processed by several classifiers. As a result, it is possible to evaluate and quantify the PD motor symptoms related to end of dose deterioration (tremor, bradykinesia, freezing of gait (FoG)) as well as those related to over-dose concentration (Levodopa-induced dyskinesia (LID)). Based on this information, together with information derived from tests performed with a virtual reality glove and information about the medication and food intake, a patient specific profile can be built. In addition, the patient specific profile with his evaluation during the last week and last month, is compared to understand whether his status is stable, improving or worsening. Based on that, the system analyses whether a medication change is needed--always under medical supervision--and in this case, information about the medication change proposal is sent to the patient. The performance of the system has been evaluated in real life conditions, the accuracy and acceptability of the system by the PD patients and healthcare professionals has been tested, and a comparison with the standard routine clinical evaluation done by the PD patients' physician has been carried out. The PERFORM system is used by the PD patients and in a simple and safe non-invasive way for long-term record of their motor status, thus offering to the clinician a precise, long-term and objective view of patient's motor status and drug/food intake. Thus, with the PERFORM system the clinician can remotely receive precise information for the PD patient's status on previous days and define the optimal therapeutical treatment.

134 citations

Journal ArticleDOI
TL;DR: In this article, a numerical approach that aims to detect, by means of interrogating microwaves, the locations and the dielectric permittivities of unknown inhomogeneous cylindrical objects of arbitrary cross sections that might be present inside a fixed area of interest is proposed.
Abstract: A numerical approach that aims to detect, by means of interrogating microwaves, the locations and the dielectric permittivities of unknown inhomogeneous dielectric cylindrical objects of arbitrary cross sections that might be present inside a fixed area of interest is proposed. An illumination is assumed with the electric field vector polarized along the cylindrical axis. The two-dimensional Lippman-Schwinger integral equation of electromagnetic scattering is transformed into matrix form by the moment method. The system obtained is solved by using a pseudoinversion algorithm to overcome ill-conditioning problems. The first-order Born approximation is also applied when the dielectric inhomogeneities are weakly scattering. Computer simulations have been performed by means of a numerical program. Results show the capabilities and limitations of the proposed approach. >

111 citations

Journal ArticleDOI
16 Sep 2014-Sensors
TL;DR: In this work the compliance of a telehealth system for the remote monitoring of Parkinson's disease patients is presented with testing in 32 PD patients and it is concluded that the acceptance of this system is satisfactory with all the levels of effect on each component scoring in the lowest ranges.
Abstract: Wearable technologies for health monitoring have become a reality in the last few years. So far, most research studies have focused on assessments of the technical performance of these systems, as well as the validation of the clinical outcomes. Nevertheless, the success in the acceptance of these solutions depends not only on the technical and clinical effectiveness, but on the final user acceptance. In this work the compliance of a telehealth system for the remote monitoring of Parkinson's disease (PD) patients is presented with testing in 32 PD patients. This system, called PERFORM, is based on a Body Area Network (BAN) of sensors which has already been validated both from the technical and clinical point for view. Diverse methodologies (REBA, Borg and CRS scales in combination with a body map) are employed to study the comfort, biomechanical and physiological effects of the system. The test results allow us to conclude that the acceptance of this system is satisfactory with all the levels of effect on each component scoring in the lowest ranges. This study also provided useful insights and guidelines to lead to redesign of the system to improve patient compliance.

90 citations

01 Jan 1995
TL;DR: This article has considered the rationale and illustrated the application of model-based parameter estimation (MBPE) to achieve reduced-order representations of electromagnetic observables via fitting models, the model- based part of MBPE, that derive from the physics of EM fields.

74 citations

Journal ArticleDOI
07 Mar 2014-Sensors
TL;DR: This work has validated the feasibility of using a Body Network Area of wireless accelerometers to perform continuous at home gait monitoring of PD patients and addresses the assessment of the system performance working in real environments.
Abstract: Parkinson's disease (PD) alters the motor performance of affected individuals. The dopaminergic denervation of the striatum, due to substantia nigra neuronal loss, compromises the speed, the automatism and smoothness of movements of PD patients. The development of a reliable tool for long-term monitoring of PD symptoms would allow the accurate assessment of the clinical status during the different PD stages and the evaluation of motor complications. Furthermore, it would be very useful both for routine clinical care as well as for testing novel therapies. Within this context we have validated the feasibility of using a Body Network Area (BAN) of wireless accelerometers to perform continuous at home gait monitoring of PD patients. The analysis addresses the assessment of the system performance working in real environments.

58 citations


Cited by
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01 Feb 2009
TL;DR: This Secret History documentary follows experts as they pick through the evidence and reveal why the plague killed on such a scale, and what might be coming next.
Abstract: Secret History: Return of the Black Death Channel 4, 7-8pm In 1348 the Black Death swept through London, killing people within days of the appearance of their first symptoms. Exactly how many died, and why, has long been a mystery. This Secret History documentary follows experts as they pick through the evidence and reveal why the plague killed on such a scale. And they ask, what might be coming next?

5,234 citations

Book
01 Jan 2009
TL;DR: A brief overview of the status of the Convention as at 3 August 2007 is presented and recent efforts of the United Nations and agencies to disseminate information on the Convention and the Optional Protocol are described.
Abstract: The present report is submitted in response to General Assembly resolution 61/106, by which the Assembly adopted the Convention on the Rights of Persons with Disabilities and the Optional Protocol thereto. As requested by the Assembly, a brief overview of the status of the Convention as at 3 August 2007 is presented. The report also contains a brief description of technical arrangements on staff and facilities made necessary for the effective performance of the functions of the Conference of States Parties and the Committee under the Convention and the Optional Protocol, and a description on the progressive implementation of standards and guidelines for the accessibility of facilities and services of the United Nations system. Recent efforts of the United Nations and agencies to disseminate information on the Convention and the Optional Protocol are also described.

2,115 citations

Journal ArticleDOI
TL;DR: Recent breakthroughs in AI technologies and their biomedical applications are outlined, the challenges for further progress in medical AI systems are identified, and the economic, legal and social implications of AI in healthcare are summarized.
Abstract: Artificial intelligence (AI) is gradually changing medical practice. With recent progress in digitized data acquisition, machine learning and computing infrastructure, AI applications are expanding into areas that were previously thought to be only the province of human experts. In this Review Article, we outline recent breakthroughs in AI technologies and their biomedical applications, identify the challenges for further progress in medical AI systems, and summarize the economic, legal and social implications of AI in healthcare.

1,315 citations

Journal ArticleDOI
TL;DR: The feasibility of detecting and localizing small (<1 cm) tumors in three dimensions with numerical models of two system configurations involving synthetic cylindrical and planar antenna arrays with image formation algorithms developed to enhance tumor responses and reduce early- and late-time clutter are demonstrated.
Abstract: The physical basis for breast tumor detection with microwave imaging is the contrast in dielectric properties of normal and malignant breast tissues. Confocal microwave imaging involves illuminating the breast with an ultra-wideband pulse from a number of antenna locations, then synthetically focusing reflections from the breast. The detection of malignant tumors is achieved by the coherent addition of returns from these strongly scattering objects. In this paper, we demonstrate the feasibility of detecting and localizing small (<1 cm) tumors in three dimensions with numerical models of two system configurations involving synthetic cylindrical and planar antenna arrays. Image formation algorithms are developed to enhance tumor responses and reduce early- and late-time clutter. The early-time clutter consists of the incident pulse and reflections from the skin, while the late-time clutter is primarily due to the heterogeneity of breast tissue. Successful detection of 6-mm-diameter spherical tumors is achieved with both planar and cylindrical systems, and similar performance measures are obtained. The influences of the synthetic array size and position relative to the tumor are also explored.

884 citations

Journal ArticleDOI
TL;DR: In this article, a simple algorithm for reconstructing the complex index of refraction of a bounded object immersed in a known background from a knowledge of how the object scatters known incident radiation is described.
Abstract: This paper describes a simple algorithm for reconstructing the complex index of refraction of a bounded object immersed in a known background from a knowledge of how the object scatters known incident radiation. The method described here is versatile accommodating both spatially and frequency varying incident fields and allowing a priori information about the scatterer to be introduced in a simple fashion. Numerical results show that this new algorithm outperforms the modified gradient approach which until now has been one of the most effective reconstruction algorithms available.

768 citations