M
Matthew A. Nystoriak
Researcher at University of Louisville
Publications - 48
Citations - 1413
Matthew A. Nystoriak is an academic researcher from University of Louisville. The author has contributed to research in topics: Medicine & Vascular smooth muscle. The author has an hindex of 16, co-authored 35 publications receiving 901 citations. Previous affiliations of Matthew A. Nystoriak include University of California, Davis & University of Vermont.
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Journal ArticleDOI
Cardiovascular Effects and Benefits of Exercise.
TL;DR: There is evidence to suggest that continuously high levels of exercise (e.g., marathon running) could have detrimental effects on cardiovascular health and further studies are needed to identify the mechanisms that impart cardiovascular benefits of exercise in order to develop more effective exercise regimens.
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Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia
Xiaozhen Dai,Xiaoqing Yan,Jun Zeng,Jing Chen,Yuehui Wang,Jun Chen,Yan Li,Michelle T. Barati,Kupper A. Wintergerst,Kejian Pan,Matthew A. Nystoriak,Daniel J. Conklin,Gregg Rokosh,Paul N. Epstein,Xiaokun Li,Yi Tan +15 more
TL;DR: Elevated expression of CXCR7 enhances EPC resistance to diabetes mellitus–induced oxidative damage and improves therapeutic efficacy of EPCs in treating diabetic limb ischemia.
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Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.
Hai Qian,Tommaso Patriarchi,Jennifer L. Price,Lucas Matt,Boram Lee,Madeline Nieves-Cintrón,Olivia R. Buonarati,Dhrubajyoti Chowdhury,Evanthia Nanou,Matthew A. Nystoriak,William A. Catterall,Montatip Poomvanicha,Franz Hofmann,Manuel F. Navedo,Johannes W. Hell,Johannes W. Hell +15 more
TL;DR: There is an unexpected dichotomy in the control of Cav1.2 by PKA in cardiomyocytes and hippocampal neurons, which implies that tissue-specific therapeutics could be identified.
Journal ArticleDOI
AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes Mellitus
Matthew A. Nystoriak,Madeline Nieves-Cintrón,Patrick J. Nygren,Simon A. Hinke,C. Blake Nichols,Chao-Yin Chen,Jose L. Puglisi,Leighton T. Izu,Donald M. Bers,Mark L. Dell'Acqua,John D. Scott,Luis Fernando Santana,Manuel F. Navedo +12 more
TL;DR: In this paper, increased contractility of arterial myocytes and enhanced vascular tone during hyperglycemia and diabetes mellitus may arise from impaired largeconductance Ca2+activated K+ (BKCa) chann
Journal ArticleDOI
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes
Matthew A. Nystoriak,Madeline Nieves-Cintrón,Tommaso Patriarchi,Olivia R. Buonarati,Maria Paz Prada,Stefano Morotti,Eleonora Grandi,Julia Dos Santos Fernandes,Katherine A. Forbush,Franz Hofmann,Kent C. Sasse,John D. Scott,Sean M. Ward,Johannes W. Hell,Manuel F. Navedo +14 more
TL;DR: Findings reveal an essential role for α1C phosphorylation at Ser1928 in stimulating CaV1.2 channel activity and vasoconstriction by AKAP-targeted PKA upon exposure to increased glucose and in diabetes.