M
Matthew A Spinelli
Researcher at University of California, San Francisco
Publications - 65
Citations - 2060
Matthew A Spinelli is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Pre-exposure prophylaxis. The author has an hindex of 18, co-authored 51 publications receiving 1072 citations. Previous affiliations of Matthew A Spinelli include University of Bologna & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Predominant Mode of Human Immunodeficiency Virus Transfer between T Cells Is Mediated by Sustained Env-Dependent Neutralization-Resistant Virological Synapses
TL;DR: The polarized T-cell morphology, Env-CD4 coordinated adhesion, and viral transfer from HIV-infected to uninfected cells suggest that VS allows HIV-1 to evade antibody neutralization and to disseminate efficiently.
Journal ArticleDOI
Common tasks in microscopic and ultrastructural image analysis using ImageJ.
Francesca Marzia Papadopulos,Matthew A Spinelli,Sabrina Valente,Laura Foroni,Catia Orrico,Francesco Alviano,Gianandrea Pasquinelli +6 more
TL;DR: The purpose of this paper is to show an alternative work method based on the usage of ImageJ, which can be effectively employed in solving common microscopic and ultrastructural image analysis tasks.
Journal ArticleDOI
The interplay between HIV and COVID-19: summary of the data and responses to date.
TL;DR: COVID-19 is threatening gains against the HIV epidemic, including the U.S. goal of Ending the HIV Epidemic goals, and higher rates of comorbidities associated with CO VID-19 disease severity among PLWH are an urgent concern.
Journal ArticleDOI
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.
Michael J. Peluso,Saki Takahashi,Jill Hakim,J. Daniel Kelly,Leonel Torres,Nikita S. Iyer,Keirstinne Turcios,Owen Janson,Sadie E. Munter,Cassandra Thanh,Joanna Donatelli,Christopher C. Nixon,Rebecca Hoh,Viva W. Tai,Emily A. Fehrman,Yanel Hernandez,Matthew A Spinelli,Monica Gandhi,Mary-Ann Palafox,Ana Vallari,Mary A. Rodgers,John Prostko,John Hackett,Lan Trinh,Terri Wrin,Christos J. Petropoulos,Charles Y. Chiu,Philip J. Norris,Clara DiGermanio,Mars Stone,Michael P. Busch,Susanna K. Elledge,Xin X. Zhou,James A. Wells,Albert Shu,Theodore W. Kurtz,John E. Pak,Wesley Wu,Peter D. Burbelo,Jeffrey I. Cohen,Rachel L. Rutishauser,Jeffrey N. Martin,Steven G. Deeks,Timothy J. Henrich,Isabel Rodriguez-Barraquer,Bryan Greenhouse +45 more
TL;DR: In this article, the authors measured antibody responses in plasma samples from 128 individuals over 160 days using 14 assays and found a consistent and strong effect of disease severity on antibody magnitude, driven by fever, cough, hospitalization, and oxygen requirement.
Journal ArticleDOI
Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms.
Michael J. Peluso,Amelia N. Deitchman,Leonel Torres,Nikita S. Iyer,Sadie E. Munter,Christopher C. Nixon,Joanna Donatelli,Cassandra Thanh,Saki Takahashi,Jill Hakim,Keirstinne Turcios,Owen Janson,Rebecca Hoh,Viva W. Tai,Yanel Hernandez,Emily A. Fehrman,Matthew A Spinelli,Monica Gandhi,Lan Trinh,Terri Wrin,Christos J. Petropoulos,Francesca T. Aweeka,Isabel Rodriguez-Barraquer,J. Daniel Kelly,Jeffrey N. Martin,Steven G. Deeks,Bryan Greenhouse,Rachel L. Rutishauser,Timothy J. Henrich +28 more
TL;DR: In this article, the authors describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T-cell responses, soluble markers of inflammation, and antibody levels and neutralization capacity longitudinally in 70 individuals with PCR-confirmed SARS CoV 2 infection.