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Matthew C. Miller

Bio: Matthew C. Miller is an academic researcher from Ohio State University. The author has contributed to research in topics: Hemodynamics & Recurrent laryngeal nerve. The author has an hindex of 6, co-authored 10 publications receiving 185 citations. Previous affiliations of Matthew C. Miller include Thomas Jefferson University & State University of New York Upstate Medical University.

Papers
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Journal ArticleDOI
TL;DR: The incidence, risk factors, prevention, and management of hypothyroidism among patients treated with radiation and other modalities for head and neck cancers is described and some evidence to suggest a protective role is suggested with respect to disease control survival inHead and neck and other cancers.
Abstract: Purpose of reviewTo describe the incidence, risk factors, prevention, and management of hypothyroidism among patients treated with radiation and other modalities for head and neck cancers.Recent findingsHypothyroidism may occur in up to 48% of patients treated for head and neck malignancies. It has

54 citations

Journal ArticleDOI
TL;DR: Methods for detecting and identifying the recurrent laryngeal nerve are explored and the evolution of functional RLN monitoring is examined, its potential advantages and disadvantages, statistical validity, and its role in the current medicolegal climate are examined.

43 citations

Journal ArticleDOI
05 Jul 2007-Thyroid
TL;DR: Routine use of intraoperative pathologic examination (IOPE) is specific, cost effective, and of minimal additional risk when performed routinely for patients with CFL or FN and reduced costs and limited the number of completion thyroidectomies necessary.
Abstract: Objective: Routine use of intraoperative pathologic examination (IOPE), including frozen section (FS) and scrape preparation cytology (SPC), during diagnostic thyroid lobectomy continues to be a source of controversy. We sought to better delineate the usefulness and cost–benefit ratio of IOPE in the context of cytologically diagnosed cellular follicular lesion (CFL) or follicular neoplasm (FN). Design: Records of 205 patients who underwent thyroidectomy for cytologically diagnosed FN or CFL between 1997 and 2005 were retrospectively reviewed. IOPE results, patient demographics, and tumor characteristics were correlated to final histopathologic diagnoses. Sensitivity, specificity, predictive values, accuracy, and costs of IOPE were calculated. Main outcome: IOPE correctly identified 3 of 16 follicular carcinomas and 9 of 36 papillary carcinomas. Sensitivity, specificity, and accuracy were 23%, 99%, and 78%, respectively. On univariate analysis, malignancy risk among follicular nodules did not correlate wit...

34 citations

Journal ArticleDOI
TL;DR: An SBP of 80 mmHg or less was concluded to be a less sensitive and physiologically less appropriate measurement of hypotension than MAP, and a threshold MAP can be utilized as a sensitive indicator of hypotensions during hemapheresis.
Abstract: Current protocols utilize systolic blood pressure (SBP) of less than 80 mmHg as objective evidence of hypotension during hemapheresis. However, tissue hypoperfusion is the pathophysiologic endpoint of low blood pressure, and mean arterial pressure (MAP), rather than SBP, is the physiologic driving force behind blood flow to organs and tissues. It is thus hypothesized that MAP is more appropriate than SBP in the assessment of hypotension and that a threshold MAP can be utilized as a sensitive indicator of hypotension during hemapheresis. Thirty-one patients who experienced hypotension during hemapheresis over a 4.5 year period reflecting forty-four hypotensive episodes were selected. The initial phase of each hemapheresis procedure provided baseline MAP and blood pressure (BP) measurements as control values. BP and MAP were then determined at the onset of subjective hypotension and compared to one another by using regression and sensitivity analyses. Correlation coefficients between SBP and MAP were found to be 0.8097 in baseline normotensive patients and 0.7725 in hypotensive patients. Sensitivity in the detection of hypotension was 0.09% for SBP equal to 80 mmHg and 56.81% for MAP equal to 70 mmHg. An SBP of 80 mmHg or less was therefore concluded to be a less sensitive and physiologically less appropriate measurement of hypotension than MAP. As a single value less than 70 mmHg or a series of successive measurements trending downward toward 70 mmHg, MAP provides an objective assessment of hypotension that may precede hemodynamic decompensation.

30 citations

Journal ArticleDOI
TL;DR: It is concluded that while CAM use was not very prevalent in this study, patients who did use it were employing modalities with biologic activity that may potentially interact with conventional therapies.
Abstract: We sought to determine the prevalence and patterns of complementary and alternative medicine (CAM) use among head and neck cancer patients who were being treated at an academic otolaryngology practice in the northeastern United States from January 2005 through December 2006. During a 3-month period, we conducted an anonymous survey of 213 new and established patients regarding their use of CAM during their cancer treatment. According to the responses, only 13 of these patients (6.1%) were currently using CAM during treatment. With respect to the various products being taken, 9 patients (69.2% of all CAM users) were taking herbs or supplements. Only 7 patients (53.8%) who used CAM disclosed this fact to their physician during in-office encounters. The most common sources for obtaining CAM were health-food stores, where most patients spent approximately $25 per week. The most frequently cited reason for using CAM was that a particular product had been recommended by family or friends as being potentially helpful. No adverse effects of CAM were reported. We conclude that while CAM use was not very prevalent in this study, patients who did use it were employing modalities with biologic activity that may potentially interact with conventional therapies. Because patients' disclosure of CAM use is frequently not volunteered, otolaryngologists should routinely elicit this information in a highly specific fashion so that we may better serve our unique patient population.

17 citations


Cited by
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Journal ArticleDOI
Gang Peng1, Tao Wang1, Kun-yu Yang1, Sheng Zhang1, Tao Zhang1, Qin Li1, Jun Han1, Gang Wu1 
TL;DR: IMRT provides improved local-recurrence free survival, especially in late-stage NPC patients and is associated with a lower incidence of toxicities, as well as significantly lower radiation-induced toxicities than those in 2D-CRT group.

478 citations

Journal ArticleDOI
TL;DR: The American Cancer Society Head and Neck Cancer Survivorship Care Guideline was developed to assist primary care clinicians and other health practitioners with the care of head and neck cancer survivors, including monitoring for recurrence, screening for second primary cancers, assessment and management of long-term and late effects, health promotion, and care coordination as discussed by the authors.
Abstract: Answer questions and earn CME/CNE The American Cancer Society Head and Neck Cancer Survivorship Care Guideline was developed to assist primary care clinicians and other health practitioners with the care of head and neck cancer survivors, including monitoring for recurrence, screening for second primary cancers, assessment and management of long-term and late effects, health promotion, and care coordination. A systematic review of the literature was conducted using PubMed through April 2015, and a multidisciplinary expert workgroup with expertise in primary care, dentistry, surgical oncology, medical oncology, radiation oncology, clinical psychology, speech-language pathology, physical medicine and rehabilitation, the patient perspective, and nursing was assembled. While the guideline is based on a systematic review of the current literature, most evidence is not sufficient to warrant a strong recommendation. Therefore, recommendations should be viewed as consensus-based management strategies for assisting patients with physical and psychosocial effects of head and neck cancer and its treatment. CA Cancer J Clin 2016;66:203-239. © 2016 American Cancer Society.

394 citations

Journal ArticleDOI
TL;DR: A truly theranostic approach with the further addition of therapeutic agents to the molecular probe for adjuvant therapy is conceivable for the future.

255 citations

Journal ArticleDOI
TL;DR: These evidence-based recommendations for surgical therapy reflect various “treatment corridors” that are best discussed within multidisciplinary teams and the patient considering tumor type, stage, progression, and inherent surgical risk.
Abstract: Introduction Over the past years, the incidence of thyroid cancer has surged not only in Germany but also in other countries of the Western hemisphere. This surge was first and foremost due to an increase of prognostically favorable (“low risk”) papillary thyroid microcarcinomas, for which limited surgical procedures are often sufficient without loss of oncological benefit. These developments called for an update of the previous practice guideline to detail the surgical treatment options that are available for the various disease entities and tumor stages.

220 citations

Journal ArticleDOI
TL;DR: Fluorescence highlighting is independent of axonal integrity, suggesting that the probe could facilitate surgical repair of injured nerves and help prevent accidental transection.
Abstract: Nerve preservation is an important goal during surgery because accidental transection or injury leads to significant morbidity, including numbness, pain, weakness or paralysis. Nerves are usually identified by their appearance and relationship to nearby structures or detected by local electrical stimulation (electromyography), but thin or buried nerves are sometimes overlooked. Here, we use phage display to select a peptide that binds preferentially to nerves. After systemic injection of a fluorescently labeled version of the peptide in mice, all peripheral nerves are clearly delineated within 2 h. Contrast between nerve and adjacent tissue is up to tenfold, and useful contrast lasts up to 8 h. No changes in behavior or activity are observed after treatment, indicating a lack of obvious toxicity. The fluorescent probe also labels nerves in human tissue samples. Fluorescence highlighting is independent of axonal integrity, suggesting that the probe could facilitate surgical repair of injured nerves and help prevent accidental transection.

195 citations