M
Matthew J. Hart
Researcher at University of Texas Health Science Center at San Antonio
Publications - 65
Citations - 8264
Matthew J. Hart is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: GTPase & Guanine nucleotide exchange factor. The author has an hindex of 32, co-authored 55 publications receiving 7912 citations. Previous affiliations of Matthew J. Hart include Harvard University & Buck Institute for Research on Aging.
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Journal ArticleDOI
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
Patricia Spilman,Natalia Podlutskaya,Matthew J. Hart,Jayanta Debnath,Olivia Gorostiza,Dale E. Bredesen,Arlan Richardson,Randy Strong,Veronica Galvan +8 more
TL;DR: It is shown that long-term inhibition of mTOR by rapamycin prevented AD-like cognitive deficits and lowered levels of Aβ42, a major toxic species in AD, in the PDAPP transgenic mouse model.
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Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
TL;DR: Overexpression of hAxin strongly promoted the downregulation of wild-type β -catenin in colon cancer cells, whereas mutant oncogenic β -Catenin was unaffected, suggesting that APC may function to derepress Axin activity.
Journal ArticleDOI
p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13
Tohru Kozasa,Xuejun Jiang,Matthew J. Hart,Pamela M. Sternweis,William D. Singer,Alfred G. Gilman,Gideon Bollag,Paul C. Sternweis +7 more
TL;DR: Members of the regulators of G protein signaling (RGS) family stimulate the intrinsic guanosine triphosphatase (GTPase) activity of the α subunits of certain heterotrimeric guanine nucleotide–binding proteins (G proteins).
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Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα13
Matthew J. Hart,Xuejun Jiang,Tohru Kozasa,William Roscoe,William D. Singer,Alfred G. Gilman,Paul C. Sternweis,Gideon Bollag +7 more
TL;DR: The GTPase activities of two G protein alpha subunits, Galpha12 and Galpha13, are stimulated by the Rho guanine nucleotide exchange factor p115 RhoGEF, which can directly link heterotrimeric G proteinalpha subunits to regulation of Rho.
Journal ArticleDOI
The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell
Matthew J. Hart,Jean-Paul Concordet,I. Lassot,Iris Albert,R. Del Los Santos,Hervé Durand,C. Perret,Bonnee Rubinfeld,Florence Margottin,Richard Benarous,Paul Polakis +10 more
TL;DR: It is concluded that β-TrCP is a component of an E3 ubiquitin ligase that is responsible for the targeted degradation of phosphorylated β-catenin.