M
Matthew J. Paszek
Researcher at Cornell University
Publications - 45
Citations - 7110
Matthew J. Paszek is an academic researcher from Cornell University. The author has contributed to research in topics: Glycocalyx & Chemistry. The author has an hindex of 16, co-authored 35 publications receiving 6213 citations. Previous affiliations of Matthew J. Paszek include University of Pennsylvania & University of California, San Francisco.
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Journal ArticleDOI
Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
Journal ArticleDOI
Balancing forces: architectural control of mechanotransduction
TL;DR: Sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.
Journal ArticleDOI
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
Matthew J. Paszek,Christopher C. DuFort,Olivier Rossier,Russell Bainer,Janna K. Mouw,Kamil Godula,Jason E. Hudak,Jonathon N. Lakins,Amanda C. Wijekoon,Luke Cassereau,Matthew G. Rubashkin,Mark Jesus M. Magbanua,Kurt S. Thorn,Michael W. Davidson,Hope S. Rugo,John W. Park,Daniel A. Hammer,Grégory Giannone,Carolyn R. Bertozzi,Valerie M. Weaver +19 more
TL;DR: A bulky glycocalyx is a feature of tumour cells that could foster metastasis by mechanically enhancing cell-surface receptor function by increasing integrin adhesion and signalling.
Journal ArticleDOI
The Tension Mounts: Mechanics Meets Morphogenesis and Malignancy
TL;DR: It will be critical to identify the key molecular elements regulating tensional-homeostasis of the mammary gland and thereafter to characterize their associated mechanotransduction pathways.
Journal ArticleDOI
Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate.
TL;DR: It is demonstrated how integrins themselves could function as sensory molecules that begin sensing matrix properties even before large multi-molecular adhesion complexes are assembled.