M
Matthew J. Whitters
Researcher at Pfizer
Publications - 62
Citations - 12443
Matthew J. Whitters is an academic researcher from Pfizer. The author has contributed to research in topics: Receptor & Immune system. The author has an hindex of 31, co-authored 62 publications receiving 12045 citations. Previous affiliations of Matthew J. Whitters include Genetics Institute, Inc. & Harvard University.
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Journal ArticleDOI
Novel regulators of bone formation: molecular clones and activities.
John M. Wozney,Vicki Rosen,Anthony J. Celeste,Lisa M. Mitsock,Matthew J. Whitters,Ronald W. Kriz,Rodney M. Hewick,Elizabeth A. Wang +7 more
TL;DR: Human complementary DNA clones corresponding to three polypeptides present in this BMP preparation have been isolated, and expression of the recombinant human proteins have been obtained, and each appears to be independently capable of inducing the formation of cartilage in vivo.
Journal ArticleDOI
CD4+CD25+ Immunoregulatory T Cells: Gene Expression Analysis Reveals a Functional Role for the Glucocorticoid-Induced TNF Receptor
Rebecca S. McHugh,Matthew J. Whitters,Ciriaco A. Piccirillo,Deborah A. Young,Ethan M. Shevach,Mary Collins,Michael C. Byrne +6 more
TL;DR: A number of genes that antagonize signaling, including members of the SOCS family, may contribute to their anergic phenotype and GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset.
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Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Anne Puel,Sophie Cypowyj,Jacinta Bustamante,Jill F. Wright,Luyan Liu,Hye Kyung Lim,Mélanie Migaud,Laura Israel,Maya Chrabieh,Magali Audry,Matthew Gumbleton,Antoine Toulon,Christine Bodemer,Jamila El-Baghdadi,Matthew J. Whitters,Theresa Paradis,Jonathan Brooks,Mary Collins,Neil M. Wolfman,Saleh Al-Muhsen,Miguel Galicchio,Laurent Abel,Laurent Abel,Capucine Picard,Jean-Laurent Casanova +24 more
TL;DR: These experiments of nature indicate that human IL-17A andIL-17F are essential for mucocutaneous immunity against C. albicans, but otherwise largely redundant.
Journal ArticleDOI
Novel Regulators of Bone Formation: Molecular Clones and Activities
John M. Wozney,Vicki Rosen,Anthony J. Celeste,Lisa M. Mitsock,Matthew J. Whitters,Ronald W. Kriz,Rodney M. Hewick,Elizabeth A. Wang +7 more
TL;DR: Human complementary DNA clones corresponding to three polypeptides present in this BMP preparation have been isolated, and expression of the recombinant human proteins have been obtained, and each appears to be independently capable of inducing the formation of cartilage in vivo.
Journal ArticleDOI
Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells
Geoffrey L. Stephens,Rebecca S. McHugh,Matthew J. Whitters,Deborah A. Young,Deborah Luxenberg,Beatriz M. Carreno,Mary Collins,Ethan M. Shevach +7 more
TL;DR: GITR-L provides an important signal for CD25− T cells, rendering them resistant to CD25+-mediated regulation at the initiation of the immune response, and may enhance the susceptibility of effector T cells to suppressor activity during the course of an infectious insult.