Matthew M. Smith

TL;DR: Findings on the genetic organization and expression strategy of HEV suggest that it is the prototype human pathogen for a new class of RNA virus or perhaps a separate genus within the Caliciviridae family.

TL;DR: This work demonstrates that the phage selection techniques enable the rapid identification of highly active and selective protease substrates without making any a priori assumptions about the specificity or the “physiological substrate” of the protease under study.

TL;DR: The importance of secondary subsites in defining both the specificity and efficiency of cleavage suggests that substrate recognition by PSA is mediated by an extended binding site, which should facilitate the development of more sensitive activity-based assays and the design of potent inhibitors.

TL;DR: It is hypothesized that, as a component of the nuclear pore complex, Ulp1 may prevent proteins from leaving the nucleus with SUMO still attached, contributing to an overall shift of SUMO from the nucleus to the cytoplasm.

TL;DR: The translated major open reading frame (ORF-1) from these clones indicates that this portion of the genome encodes a polyprotein with consensus sequences found in RNA-dependent RNA polymerase and ATP/GTP binding domains that has been associated with putative helicases of positive-strand RNA viruses.