M
Matthew P. Fletcher
Researcher at University of Nottingham
Publications - 14
Citations - 1595
Matthew P. Fletcher is an academic researcher from University of Nottingham. The author has contributed to research in topics: Quorum sensing & Pseudomonas aeruginosa. The author has an hindex of 9, co-authored 14 publications receiving 1384 citations.
Papers
More filters
Journal ArticleDOI
Quinolones: from antibiotics to autoinducers
Stephan Heeb,Matthew P. Fletcher,Siri Ram Chhabra,Stephen P. Diggle,Paul Williams,Miguel Cámara +5 more
TL;DR: This work reviews selectively this extensive family of bicyclic compounds, from natural and synthetic antimicrobials to signalling molecules, with a special emphasis on the biology of P. aeruginosa.
Journal ArticleDOI
The Pseudomonas aeruginosa 4-Quinolone Signal Molecules HHQ and PQS Play Multifunctional Roles in Quorum Sensing and Iron Entrapment
Stephen P. Diggle,Sandra Matthijs,Victoria Wright,Matthew P. Fletcher,Siri Ram Chhabra,Iain L. Lamont,Xiaole Kong,Robert C. Hider,Pierre Cornelis,Miguel Cámara,Paul Williams +10 more
TL;DR: Biophysical analysis revealed that 2-alkyl-3-hydroxy-4-quinolones form complexes with iron(III) at physiological pH, and a secondary function for PQS in iron entrapment to facilitate siderophore-mediated iron delivery is revealed.
Journal ArticleDOI
Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR).
Aravindan Ilangovan,Matthew P. Fletcher,Giordano Rampioni,Christian Pustelny,Kendra P. Rumbaugh,Stephan Heeb,Miguel Cámara,Alex Truman,Siri Ram Chhabra,Jonas Emsley,Paul Williams +10 more
TL;DR: Novel insights are presented into LTTR ligand binding and ligand-based drug design and a chemical scaffold for further anti-P.
Journal ArticleDOI
Transcriptomic analysis reveals a global alkyl-quinolone-independent regulatory role for PqsE in facilitating the environmental adaptation of Pseudomonas aeruginosa to plant and animal hosts.
Giordano Rampioni,Christian Pustelny,Matthew P. Fletcher,Victoria Wright,Mary Bruce,Kendra P. Rumbaugh,Stephan Heeb,Miguel Cámara,Paul Williams +8 more
TL;DR: PqsE is a key regulator within the QS circuitry facilitating the environmental adaptation of P. aeruginosa, and was required for swarming motility and virulence in plant and animal infection models in the absence of AQs.
Journal ArticleDOI
Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa.
Giordano Rampioni,Giordano Rampioni,Marilena Falcone,Stephan Heeb,Emanuela Frangipani,Emanuela Frangipani,Matthew P. Fletcher,Jean-Frédéric Dubern,Paolo Visca,Livia Leoni,Miguel Cámara,Paul Williams +11 more
TL;DR: In this article, the pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents.