M
Matthew P. McCusker
Researcher at University College Dublin
Publications - 17
Citations - 813
Matthew P. McCusker is an academic researcher from University College Dublin. The author has contributed to research in topics: Salmonella enterica & Efflux. The author has an hindex of 11, co-authored 17 publications receiving 688 citations. Previous affiliations of Matthew P. McCusker include European Commission.
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Journal ArticleDOI
The ins and outs of RND efflux pumps in Escherichia coli
TL;DR: Current knowledge on resistance-nodulation-cell division efflux mechanisms in E. coli is summarized to allow the development of combined therapies using efflux inhibitors together with antibiotics to act on Gram-negative bacteria, such as the emerging globally disseminated MDR pathogen Escherichia coli ST131.
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Salmonella-host interactions - modulation of the host innate immune system.
TL;DR: This review outlines salmonellosis and the clinical manifestations between typhoidal and NTS infections as well as discussing the host immune response to infection and the models that are being used to elucidate the mechanisms involved in Salmonella pathogenicity.
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Multiple Regulatory Pathways Associated with High-Level Ciprofloxacin and Multidrug Resistance in Salmonella enterica Serovar Enteritidis: Involvement of ramA and Other Global Regulators
Edel O'Regan,Teresa Quinn,Jean-Marie Pagès,Matthew P. McCusker,Laura J. V. Piddock,Séamus Fanning +5 more
TL;DR: Both efflux activity and a single gyrA mutation contribute to nalidixic acid resistance and reduced ciprofloxacin sensitivity.
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A Simple Method for Assessment of MDR Bacteria for Over-Expressed Efflux Pumps.
Marta Martins,Matthew P. McCusker,Miguel Viveiros,Isabel Couto,Séamus Fanning,Séamus Fanning,Jean-Marie Pagès,Leonard Amaral +7 more
TL;DR: The presumptive efflux activity detected by the Ethidium Bromide-agar Cartwheel method was subsequently confirmed by the determination of the minimum inhibitory concentration for several antibiotics in the presence and absence of known efflux pump inhibitors.
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Characterization of antimicrobial resistance in Salmonella enterica food and animal isolates from Colombia: identification of a qnrB19‐mediated quinolone resistance marker in two novel serovars
Maria Karczmarczyk,Marta Martins,Marta Martins,Matthew P. McCusker,Salim Mattar,Leonard Amaral,Nola Leonard,Frank Møller Aarestrup,Séamus Fanning +8 more
TL;DR: This study demonstrates the occurrence of the qnrB19 gene associated with small ColE plasmids hitherto unrecognized in various Salmonella serovars in Colombia and reports unusual high-level quinolone resistance in the absence of any DNA gyrase mutations in serovar S. Carrau, Muenchen and Uganda.