Author
Matthew Paul
Bio: Matthew Paul is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Vascular endothelial growth factor A & Kinase insert domain receptor. The author has an hindex of 1, co-authored 1 publications receiving 89 citations.
Papers
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TL;DR: It is demonstrated that both perlecan and endorepellin bind directly and with high affinity to both VEGF receptors 1 and 2, in a region that differs from VEGFA-binding site, and hypothesized that a mechanism such as dual receptor antagonism could operate for other angiostatic fragments.
98 citations
TL;DR: In this article , the epigenetic mechanisms that underlie persistent genome-wide signatures of stress coping were examined, showing that a single exposure to acute stress has long-term functional and structural consequences in the hippocampus.
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TL;DR: The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants and is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores.
856 citations
TL;DR: Developmental, structural and biochemical aspects of basement membranes are addressed and some of the pathogenetic mechanisms causing diseases linked to abnormal basement membrane diseases are discussed.
358 citations
University of Patras1, Foundation for Research & Technology – Hellas2, Aichi Medical University3, University of Bologna4, University of Reims Champagne-Ardenne5, University of Münster6, University of Insubria7, Centre national de la recherche scientifique8, University of Alabama at Birmingham9, Thomas Jefferson University10
TL;DR: The primary goal of this comprehensive review is to summarize major achievements and paradigm-shifting discoveries made on the PG/GAG chemistry-biology axis, focusing on structural variability, structure-function relationships, metabolic, molecular, and epigenetic mechanisms underlying their synthesis.
Abstract: The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural network comprised of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs), collagens, laminins, fibronectin, elastin, other glycoproteins and proteinases In recent years, the field of PGs has expanded rapidly Due to their high structural complexity and heterogeneity, PGs mediate several homeostatic and pathological processes PGs consist of a protein core and one or more covalently attached GAG chains, which provide the protein cores with the ability to interact with several proteins The GAG building blocks of PGs significantly influence the chemical and functional properties of PGs The primary goal of this comprehensive review is to summarize major achievements and paradigm-shifting discoveries made on the PG/GAG chemistry-biology axis, focusing on structural variability, structure-function relationships, metabolic, molecular, and epigenetic mechanisms underlying their synthesis Recent insights related to exosome biogenesis, degradation, and cell signaling, their status as diagnostic tools and potential pharmacological targets in diseases as well as current applications in nanotechnology and biotechnology are addressed Moreover, issues related to docking studies, molecular modeling, GAG/PG interaction networks, and their integration are discussed
226 citations
TL;DR: This collection of expertly-written reviews aims to relay state-of-the-art information concerning the mechanisms of matrix modeling and remodeling in physiological development and disease.
177 citations
TL;DR: The ability to understand and modulate matrix-related mechanisms may lead to the future discovery of novel therapeutic options for patients with human malaises including connective tissue disorders, muscular dystrophy, fibrosis, and cancer.
163 citations