M
Matthias Frank
Researcher at Lawrence Livermore National Laboratory
Publications - 179
Citations - 10664
Matthias Frank is an academic researcher from Lawrence Livermore National Laboratory. The author has contributed to research in topics: Laser & Superconducting tunnel junction. The author has an hindex of 42, co-authored 176 publications receiving 9603 citations. Previous affiliations of Matthias Frank include University of California, Davis.
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Journal ArticleDOI
Femtosecond X-ray protein nanocrystallography
Henry N. Chapman,Petra Fromme,Anton Barty,Thomas A. White,Richard A. Kirian,Andrew Aquila,Mark S. Hunter,Joachim Schulz,Daniel P. DePonte,Uwe Weierstall,R. Bruce Doak,Filipe R. N. C. Maia,Andrew V. Martin,Ilme Schlichting,Lukas Lomb,Nicola Coppola,Robert L. Shoeman,Sascha W. Epp,Robert Hartmann,Daniel Rolles,Artem Rudenko,Lutz Foucar,Nils Kimmel,Georg Weidenspointner,Peter Holl,Mengning Liang,Miriam Barthelmess,Carl Caleman,Sébastien Boutet,Michael J. Bogan,Jacek Krzywinski,Christoph Bostedt,Saša Bajt,Lars Gumprecht,Benedikt Rudek,Benjamin Erk,Carlo Schmidt,André Hömke,Christian Reich,Daniel Pietschner,Lothar Strüder,Günter Hauser,H. Gorke,Joachim Ullrich,Sven Herrmann,Gerhard Schaller,Florian Schopper,Heike Soltau,Kai-Uwe Kühnel,Marc Messerschmidt,John D. Bozek,Stefan P. Hau-Riege,Matthias Frank,Christina Y. Hampton,Raymond G. Sierra,Dmitri Starodub,Garth J. Williams,Janos Hajdu,Nicusor Timneanu,M. Marvin Seibert,M. Marvin Seibert,Jakob Andreasson,Andrea Rocker,Olof Jönsson,Martin Svenda,Stephan Stern,Karol Nass,Robert Andritschke,Claus Dieter Schröter,Faton Krasniqi,Mario Bott,Kevin Schmidt,Xiaoyu Wang,Ingo Grotjohann,James M. Holton,Thomas R. M. Barends,Richard Neutze,Stefano Marchesini,Raimund Fromme,Sebastian Schorb,Daniela Rupp,M. Adolph,Tais Gorkhover,Inger Andersson,Helmut Hirsemann,Guillaume Potdevin,Heinz Graafsma,Björn Nilsson,John C. H. Spence +88 more
TL;DR: This work offers a new approach to structure determination of macromolecules that do not yield crystals of sufficient size for studies using conventional radiation sources or are particularly sensitive to radiation damage, by using pulses briefer than the timescale of most damage processes.
Journal ArticleDOI
Femtosecond diffractive imaging with a soft-X-ray free-electron laser
Henry N. Chapman,Henry N. Chapman,Anton Barty,Michael J. Bogan,Sébastien Boutet,Sébastien Boutet,Sébastien Boutet,Matthias Frank,Stefan P. Hau-Riege,Stefano Marchesini,Stefano Marchesini,Bruce W. Woods,Saša Bajt,W. Henry Benner,Richard A. London,Richard A. London,Elke Plönjes,Marion Kuhlmann,Rolf Treusch,Stefan Düsterer,Thomas Tschentscher,Jochen R. Schneider,Eberhard Spiller,Thomas Möller,Christoph Bostedt,Matthias Hoener,David A. Shapiro,Keith O. Hodgson,David van der Spoel,F. Burmeister,M. Bergh,Carl Caleman,G. Huldt,M. Marvin Seibert,Filipe R. N. C. Maia,Richard W. Lee,Richard W. Lee,Abraham Szöke,Abraham Szöke,Nicusor Timneanu,Janos Hajdu,Janos Hajdu +41 more
TL;DR: In this paper, the FLASH soft X-ray free-electron laser was used to reconstruct a coherent diffraction pattern from a nano-structured nonperiodic object, before destroying it at 60,000 K.
Journal ArticleDOI
Single mimivirus particles intercepted and imaged with an X-ray laser
M. Marvin Seibert,Tomas Ekeberg,Filipe R. N. C. Maia,Martin Svenda,Jakob Andreasson,Olof Jönsson,Dusko Odic,Bianca Iwan,Andrea Rocker,Daniel Westphal,Max F. Hantke,Daniel P. DePonte,Anton Barty,Joachim Schulz,Lars Gumprecht,Nicola Coppola,Andrew Aquila,Mengning Liang,Thomas A. White,Andrew V. Martin,Carl Caleman,Stephan Stern,Chantal Abergel,Virginie Seltzer,Jean-Michel Claverie,Christoph Bostedt,John D. Bozek,Sébastien Boutet,A. Miahnahri,Marc Messerschmidt,Jacek Krzywinski,Garth J. Williams,Keith O. Hodgson,Michael J. Bogan,Christina Y. Hampton,Raymond G. Sierra,D. Starodub,Inger Andersson,Sǎa Bajt,Miriam Barthelmess,John C. H. Spence,Petra Fromme,Uwe Weierstall,Richard A. Kirian,Mark S. Hunter,R. Bruce Doak,Stefano Marchesini,Stefan P. Hau-Riege,Matthias Frank,Robert L. Shoeman,Lukas Lomb,Sascha W. Epp,Robert Hartmann,Daniel Rolles,Artem Rudenko,Carlo Schmidt,Lutz Foucar,Nils Kimmel,Peter Holl,Benedikt Rudek,Benjamin Erk,André Hömke,Christian Reich,Daniel Pietschner,Georg Weidenspointner,Lothar Strüder,Günter Hauser,H. Gorke,Joachim Ullrich,Ilme Schlichting,Sven Herrmann,Gerhard Schaller,Florian Schopper,Heike Soltau,Kai Uwe Kuhnel,Robert Andritschke,Claus Dieter Schröter,Faton Krasniqi,Mario Bott,Sebastian Schorb,Daniela Rupp,M. Adolph,Tais Gorkhover,Helmut Hirsemann,Guillaume Potdevin,Heinz Graafsma,Björn Nilsson,Henry N. Chapman,Janos Hajdu +88 more
TL;DR: This work shows that high-quality diffraction data can be obtained with a single X-ray pulse from a non-crystalline biological sample, a single mimivirus particle, which was injected into the pulsed beam of a hard-X-ray free-electron laser, the Linac Coherent Light Source.
Journal ArticleDOI
Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser
Lars Redecke,Lars Redecke,Karol Nass,Daniel P. DePonte,Thomas A. White,Dirk Rehders,Anton Barty,Francesco Stellato,Mengning Liang,Thomas R. M. Barends,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,M. Marvin Seibert,Andrew Aquila,David Arnlund,Saša Bajt,Torsten Barth,Michael J. Bogan,Carl Caleman,Tzu-Chiao Chao,R. Bruce Doak,Holger Fleckenstein,Matthias Frank,Raimund Fromme,Lorenzo Galli,Ingo Grotjohann,Mark S. Hunter,Linda C. Johansson,Stephan Kassemeyer,Gergely Katona,Richard A. Kirian,Rudolf Koopmann,Chris Kupitz,Lukas Lomb,Andrew V. Martin,Stefan Mogk,Richard Neutze,Robert L. Shoeman,Jan Steinbrener,Nicusor Timneanu,Dingjie Wang,Uwe Weierstall,Nadia A. Zatsepin,John C. H. Spence,Petra Fromme,Ilme Schlichting,Michael Duszenko,Christian Betzel,Henry N. Chapman +49 more
TL;DR: The structure reveals the mechanism of native TbCatB inhibition and demonstrates that new biomolecular information can be obtained by the “diffraction-before-destruction” approach of x-ray free-electron lasers from hundreds of thousands of individual microcrystals.
Journal ArticleDOI
Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser.
Christopher Kupitz,Shibom Basu,Ingo Grotjohann,Raimund Fromme,Nadia A. Zatsepin,Kimberly N. Rendek,Mark S. Hunter,Mark S. Hunter,Robert L. Shoeman,Thomas A. White,Dingjie Wang,Daniel James,Jay-How Yang,Danielle E. Cobb,Brenda Reeder,Raymond G. Sierra,Haiguang Liu,Anton Barty,Andrew Aquila,Daniel P. DePonte,Richard A. Kirian,Sadia Bari,Jesse J. Bergkamp,Kenneth R. Beyerlein,Michael J. Bogan,Carl Caleman,Tzu-Chiao Chao,Tzu-Chiao Chao,Chelsie E. Conrad,Katherine M. Davis,Holger Fleckenstein,Lorenzo Galli,Stefan P. Hau-Riege,Stephan Kassemeyer,Hartawan Laksmono,Mengning Liang,Lukas Lomb,Stefano Marchesini,Andrew V. Martin,Marc Messerschmidt,Despina Milathianaki,Karol Nass,Alexandra Ros,Shatabdi Roy-Chowdhury,Kevin Schmidt,M. Marvin Seibert,M. Marvin Seibert,Jan Steinbrener,Francesco Stellato,Lifen Yan,Chun Hong Yoon,Thomas A. Moore,Ana L. Moore,Yulia Pushkar,Garth J. Williams,Sébastien Boutet,R. Bruce Doak,Uwe Weierstall,Matthias Frank,Henry N. Chapman,John C. H. Spence,Petra Fromme +61 more
TL;DR: Time resolved experiments on PSII nano/microcrystals from Thermosynechococcus elongatus performed with the recently developed technique of serial femtosecond crystallography provide evidence that PSII undergoes significant conformational changes at the electron acceptor side and at the Mn4CaO5 core of the OEC.