Matthias Schlesner

TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.

TL;DR: The power of ComplexHeatmap is demonstrated to easily reveal patterns and correlations among multiple sources of information with four real-world datasets.

TL;DR: The circlize package is presented, which provides an implementation of circular layout generation in R as well as an enhancement of available software and the flexibility of this package is based on the usage of low-level graphics functions such that self-defined high- level graphics can be easily implemented by users for specific purposes.

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The data suggest that 7–8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.