Maud Reiter

TL;DR: A combination of X-ray crystallographic data, deuterium labeling, and chemical correlation studies provides further evidence as to the correct absolute stereochemical assignment of (+)-frondosin B.

TL;DR: The application of miniaturized high-throughput experimentation methods to resolve synthetic chemistry challenges on the frontlines of a lead optimization effort to develop diacylglycerol acyltransferase (DGAT1) inhibitors is demonstrated.

TL;DR: This work has shown that a conceptually novel biocatalytic approach to hetero-Diels-Alder (HDA) adducts derived from carbonyl dienophiles has been developed mirroring a stepwise aldol Michael mechanism instead of a concerted pathway, and is best applied for the preparation of enantioenriched HDA adduction derived from poorly electrophilic acceptors.

TL;DR: The sole product of the oxidative cyclization of alpha,beta-dihydroxyenone was a five-membered furan-3(2H)-one derivative, suggesting that the ring closure of these diols is both chemo- and regioselective.

TL;DR: Experimental results suggest that C=O coordination was the preferred mode of activation for reactions performed in the presence of Al(ClO(4) x 9 H(2)O or [Pd(MeCN)(4)](BF(4))(2), and this catalyst can promote enolisation.