Maureen Long

Bio: Maureen Long is an academic researcher from University of California, Merced. The author has contributed to research in topics: Shape-memory polymer & Surface plasmon resonance. The author has an hindex of 4, co-authored 6 publications receiving 491 citations.

Tunable Nanowrinkles on Shape Memory Polymer Sheets

Abstract: (Figure Presented) Controllable biaxial and uniaxial nanowrinkles (see figure) are fabricated by a simple two-step approach - metal deposition and subsequent heating - based on shape memory polymer (prestressed polystyrene) sheets. The wavelengths of the wrinkles can be tuned by controlling the thickness of deposited metal. The ready integration of the nanowrinkles into microchannels and their effectiveness in surface enhanced sensing is demonstrated. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

Shrinky-Dink microfluidics: rapid generation of deep and rounded patterns.

Abstract: We present a rapid and non-photolithographic approach to microfluidic pattern generation by leveraging the inherent shrinkage properties of biaxially oriented polystyrene thermoplastic sheets. This novel approach yields channels deep enough for mammalian cell assays, with demonstrated heights up to 80 µm. Moreover, we can consistently and easily achieve rounded channels, multi-height channels, and channels as thin as 65 µm in width. Finally, we demonstrate the utility of this simple microfabrication approach by fabricating a functional gradient generator. The whole process—from device design conception to working device—can be completed within minutes.

A simple three-dimensional vortex micromixer

Abstract: We demonstrate rapid homogenous micromixing at low Reynolds numbers in an easily fabricated and geometrically simple three-dimensional polystyrene vortex micromixer. Micromixing is critically important for miniaturized analysis systems. However, rapid and effective mixing at these small scales remains a persistent challenge. We compare our micromixer’s performance against a two-dimensional square-wave design by examining its effectiveness in mixing solutions of dissimilar concentration as well as suspension solutions comprised of microparticles. Numerical simulations confirm our experimental observations and provide insights on the self-rotational mixing dynamics achieved with our simple geometry at low Reynolds numbers. This rapid, robust, and easily fabricated micromixer is amenable readily to large scale integration.

Bimetallic nanopetals for thousand-fold fluorescence enhancements

Abstract: We present a simple, ultra-rapid and robust method to create sharp nanostructures—nanopetals—in a shape memory polymer substrate demonstrating unprecedented enhancements for surface enhanced sensing over large surface areas. These bimetallic nanostructures demonstrate extremely strong surface plasmon resonance effects due to the high density multifaceted petal structures that increase the probability of forming nanogaps. We demonstrate that our nanopetals exhibit extremely strong surface plasmons, confining the emission and enhancing the fluorescence intensity of the nearby high-quantum yield fluorescein by >4000×. The enhancements are confined to the extremely small volumes at the nanopetal borders. This enables us to achieve single molecule detection at relatively high and physiological concentrations.

Scattering of light by molecules over a rough surface

Abstract: We present a theory for the multiple scattering of light by obstacles situated over a rough surface. This problem is important for applications in biological and chemical sensors. To keep the formulation of this theory simple, we study scalar waves. This theory requires knowledge of the scattering operator (t-matrix) for each of the obstacles as well as the reflection operator for the rough surface. The scattering operator gives the field scattered by the obstacle due to an exciting field incident on the scatterer. The reflection operator gives the field reflected by the rough surface due to an exciting field incident on the rough surface. We apply this general theory for the special case of point scatterers and a slightly rough surface with homogeneous Dirichlet and Neumann boundary conditions. We show examples that demonstrate the utility of this theory.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Point of care diagnostics: Status and future

Abstract: Introduction A Why POC Diagnostics? B Time B Patient Responsibility and Compliance B Cost B Diagnostic Targets C Proteins C Metabolites and Other Small Molecules C Nucleic Acids C Human Cells D Microbes/Pathogens D Drugs and Food Safety D Current Context of POC Assays E POC Glucose Assays E Lateral Flow Assays E Limitations of “Traditional” POC Approaches F Enabling Technologies G Printing and Laminating G Microfluidic Technologies and Approaches: “Unit Operations” for POC Devices G Pumping and Valving H Mixing I Separation I Reagent Storage J Sample Preparation K Surface Chemistry and Device Substrates L Physical Adsorption L Bioaffinity Attachment L Covalent Attachment M Substrate Materials M Detection M Electrochemical Detection N Optical Detection N Magnetic Detection N Label-Free Methods O Enabling Multiplexed Assays O Recent Innovation O Lateral Flow Assay Technologies O Proteins P Antibodies P Protein Expression and Purification Q Nucleic Acids Q Aptamers R Infectious Diseases and Food/Water Safety R Blood Chemistry S Coagulation Markers S Whole Cells S Trends, Unmet Needs, Perspectives T Glucose T Global Health and the Developing World T Personalized Medicine and Home Testing U Technology Trends U Multiplexing V Author Information V Biographies V Acknowledgment W References W