M
Maurits C.E.F. Wijffels
Researcher at Leiden University Medical Center
Publications - 59
Citations - 7608
Maurits C.E.F. Wijffels is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Atrial fibrillation & Catheter ablation. The author has an hindex of 28, co-authored 56 publications receiving 7310 citations. Previous affiliations of Maurits C.E.F. Wijffels include Hospital General Universitario Gregorio Marañón & Maastricht University.
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Journal ArticleDOI
Atrial Fibrillation Begets Atrial Fibrillation A Study in Awake Chronically Instrumented Goats
TL;DR: Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF.
Journal ArticleDOI
Structural Changes of Atrial Myocardium due to Sustained Atrial Fibrillation in the Goat
Jannie Ausma,Maurits C.E.F. Wijffels,Fred Thoné,Luc Wouters,Maurits A. Allessie,Marcel Borgers +5 more
TL;DR: This goat model of AF offers a new approach to study the cascade of events leading to sustained AF and its maintenance, and leads to predominantly structural changes in the atrial myocytes similar to those seen in ventricular myocytes from chronic hibernating myocardium.
Journal ArticleDOI
Electrical remodeling due to atrial fibrillation in chronically instrumented conscious goats: roles of neurohumoral changes, ischemia, atrial stretch, and high rate of electrical activation.
Maurits C.E.F. Wijffels,Charles J. H. J. Kirchhof,Rick Dorland,John M. Power,Maurits A. Allessie +4 more
TL;DR: Electrical remodeling by AF is not mediated by changes in autonomic tone, ischemia, Stretch, stretch, or ANF, and the high rate of electrical activation itself provides the stimulus for the AF-induced changes in AERP.
Journal ArticleDOI
Verapamil Reduces Tachycardia-Induced Electrical Remodeling of the Atria
Robert G. Tieleman,Cees D.J. De Langen,Isabelle C. Van Gelder,Pieter J de Kam,Jan G. Grandjean,KJ Bel,Maurits C.E.F. Wijffels,Maurits A. Allessie,Harry J.G.M. Crijns +8 more
TL;DR: Electrical remodeling of the atrium during rapid atrial pacing was significantly attenuated by verapamil, which suggests that electrical remodelling of theAtrial effective refractory period is triggered by the high calcium influx during rapidatrial pacing rates.
Journal ArticleDOI
Atrial Fibrillation Catheter Ablation Versus Surgical Ablation Treatment (FAST) A 2-Center Randomized Clinical Trial
Lucas V.A. Boersma,Manuel Castellá,Wim-Jan van Boven,Antonio Berruezo,Alaaddin Yilmaz,Mercedes Nadal,Elena Sandoval,Naiara Calvo,Josep Brugada,Johannes Kelder,Maurits C.E.F. Wijffels,Lluís Mont +11 more
TL;DR: A randomized clinical trial comparing the efficacy and safety of catheter ablation and minimally invasive surgical ablation during a 12-month follow-up was described in this article. But the primary end point, freedom from left atrial arrhythmia >30 seconds without antiarrhythmic drugs after 12 months, was 36.5% for CA and 65.6% for SA (P=0.0022).