M
Mauro Modesti
Researcher at Aix-Marseille University
Publications - 84
Citations - 5219
Mauro Modesti is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: DNA repair & DNA. The author has an hindex of 35, co-authored 75 publications receiving 4553 citations. Previous affiliations of Mauro Modesti include McMaster University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
Pierre-Olivier Mari,Bogdan I. Florea,Stephan P. Persengiev,Nicole S. Verkaik,Hennie T. Brüggenwirth,Mauro Modesti,Giuseppina Giglia-Mari,Karel Bezstarosti,Jeroen Demmers,Theo M. Luider,Adriaan B. Houtsmuller,Dik C. van Gent +11 more
TL;DR: Evidence is provided that a pulsed near IR laser can produce DSBs without any visible alterations in the nucleus, and it is shown that NHEJ proteins accumulate in the irradiated areas, and that XRCC4 may serve as a flexible tether between Ku70/80 and ligase IV.
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Rab6 Regulates Transport and Targeting of Exocytotic Carriers
Ilya Grigoriev,Daniël Splinter,Nanda Keijzer,Phebe S. Wulf,Jeroen Demmers,Toshihisa Ohtsuka,Mauro Modesti,Ivan V. Maly,Frank Grosveld,Casper C. Hoogenraad,Anna Akhmanova +10 more
TL;DR: It is shown that the small GTPase Rab6 marks exocytotic vesicles and, together with the microtubule plus-end-directed motor kinesin-1, stimulates their processive microtubules-based transport to the cell periphery.
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The structure‐specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double‐strands breaks
Katsuhiro Hanada,Magda Budzowska,Mauro Modesti,Alex Maas,Claire Wyman,Jeroen Essers,Roland Kanaar +6 more
TL;DR: Mus81, a component of the Mus81–Eme1 structure‐specific endonuclease, is involved in generating the ICL‐induced DSBs in mouse embryonic stem (ES) cells in S phase and it is proposed that Mus81- and Rad54‐mediated homologous recombination are involved in the same DNA replication‐dependent ICL repair pathway.
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Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging
Joost van Mameren,Peter Gross,Géraldine Farge,Pleuni Hooijman,Mauro Modesti,Maria Falkenberg,Gijs J.L. Wuite,Erwin J.G. Peterman +7 more
TL;DR: The structural basis of DNA overstretching is resolved using a combination of fluorescence microscopy, optical tweezers, and microfluidics and it is found that these conversions favorably initiate from nicks or free DNA ends, serving as energetically favorable nucleation points for melting.
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Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization
Gideon Lansbergen,Yulia Komarova,Yulia Komarova,Mauro Modesti,Claire Wyman,Casper C. Hoogenraad,Holly V. Goodson,Regis P. Lemaitre,David N. Drechsel,Erik B. van Munster,Theodorus W. J. Gadella,Frank Grosveld,Niels Galjart,Gary G. Borisy,Anna Akhmanova +14 more
TL;DR: It is proposed that conformational changes in CLIP-170 are important for binding to dynactin, LIS1, and the MT tips, and it is shown that down-regulation of CLip-170 by RNA interference results in a strongly reduced accumulation of Dynactin at theMT tips.