Mawardi Rahmani

Bio: Mawardi Rahmani is an academic researcher from Universiti Putra Malaysia. The author has contributed to research in topics: Friedelin & Xanthone. The author has an hindex of 24, co-authored 115 publications receiving 1871 citations.

CHEMICAL CONSTITUENTS FROM TWO WEED SPECIES OF SPERMACOCE (RUBIACEAE) (Kandungan Kimia daripada Dua Spesies Rerumput Spermacoce ( Rubiaceae))

Abstract: Spermacoce articularis and Spermacoce exilis are weeds commonly growing in wastelands but widely used as traditional medicines. The separation works on the two plant species had been carried out using various solvents and chromatographic methods. The structures of the isolated compounds were determined by using spectroscopic methods such as IR, MS, 1 H NMR, 13 C NMR, 2D-NMR and by comparison with the data reported previously. Extracts from Spermacoce articularis gave two compounds, identified as ursolic acid (1) and stigmasterol, while extracts from Spermacoce exilis yielded four compounds, ursolic acid (1), benzo[g]isoquinoline-5,10-dione (2), stigmasterol and hexadecanoic acid (3). There was no previous phytochemical investigation on Spermacoce exilis.

Chemical constituents from two weed species of Spermacoce (Rubiaceae)

Abstract: Spermacoce articularis and Spermacoce exilisare weeds commonly growing in wastel ands but widely used as traditional medicines. The separation works on the two plant species had been carried out using various solvents and chromatographic methods. The structures of the isolated compounds were determined by using spectroscopic methods such as IR, MS, 1H NMR, 13C NMR, 2D-NMR and by comparison with the data reported previously. Extracts from Spermacoce articularis gave two compounds, identified as ursolic acid (1)and stigmasterol, while extracts from Spermacoce exilis yielded four compounds, ursolic acid(1), benzo[g]isoquinoline-5, 10-dione(2), stigmasterol and hexadecanoic acid(3). There was no previous phytochemical investigation on Spermacoce exilis.

Polysubstituted Flavonoids from the Leaves of Murraya paniculata (Rutaceae)

Abstract: Chemical studies on the constituents of the leaves of Murraya paniculata (Lynn) Jack have furnished three highly-oxygenated flavonoids; gardenin E (1), gardenin A (2), and gardenin C (3). Structures of the compounds were elucidated based on NMR, MS, UV, IR data and also by comparison with the previous works. The antimicrobial activities of these compounds and the crude extracts were also evaluated.

A Novel Cyclodione Coumarin from the Stem Bark of Mesua beccariana

Abstract: Our ongoing investigations on the stem bark of Mesua beccariana afforded a novel cyclodione coumarin, beccamarin, together with two known xanthones, mesuarianone, mesuasinone, two anthraquinones, 4-methoxy-1,3,5-trihydroxy-anthraquinone and 2,5-dihydroxy-1,3,4-trimethoxyanthraquinone and one coumarin, mammea A/AB. The structures were elucidated by 1D and 2D NMR and MS techniques.

Chalcone: A Privileged Structure in Medicinal Chemistry.

Abstract: Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

The Wealth of India

Abstract: IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)