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Mawardi Rahmani

Bio: Mawardi Rahmani is an academic researcher from Universiti Putra Malaysia. The author has contributed to research in topics: Friedelin & Xanthone. The author has an hindex of 24, co-authored 115 publications receiving 1871 citations.


Papers
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Journal ArticleDOI
TL;DR: The ground air-dried stem bark of Artocarpus kemando Miq. (Moraceae) collected from Sarawak, Malaysia was subjected to sequential extraction with hexane, chloroform and methanol to give three crude extracts as mentioned in this paper.
Abstract: The ground air-dried stem bark of Artocarpus kemando Miq. (Moraceae) collected from Sarawak, Malaysia was subjected to sequential extraction with hexane, chloroform and methanol to give three crude extracts. Silica gel chromatographic separation of the chloroform extract yielded a dipeptide, aurantiamide benzoate, cycloartobiloxanthone, dihydroartoindonesianin C and 6,7-dimethoxycoumarin. All compounds were obtained as crystals and their structures were determined on the basis of spectroscopic data, including UV, IR, MS, 1D- and 2D-NMR and comparison with known related compounds. This is the first report on the identification of a peptide in Artocarpus species.

7 citations

01 Jan 2013
TL;DR: One new carbazole alkaloid, 1,8-dihydroxy-3-formyl-4- prenylcarbazole (Clausine–TH), and two other known compounds, Clausenarin (coumarin) and Clausine–K (carbazoles alkaloids) were isolated from the methanol extract of the stem bark of Clausena excavata, collected from Kedah, Malaysia.
Abstract: Malaysia is one of the richest in its biodiversity in the world. There are not less than 12,000 plants species in its rain forest. The aim of this study is a continuous investigation for medicinal plants in Malaysia, especially the chemical constituents that are poses significant activities, i.e. anti-cancer. Clausena excavata (Rutaceae) has been known as a very rich in carbazole alkaloids, coumarins and limonoids species. In the present study, one new carbazole alkaloid, 1,8-dihydroxy-3-formyl-4- prenylcarbazole (Clausine–TH), and two other known compounds, Clausenarin (coumarin) and Clausine–K (carbazole alkaloid), were isolated from the methanol extract of the stem bark of Clausena excavata, collected from Kedah, Malaysia. Structures of these compounds were confirmed by various spectroscopic analyses including GC-MS, NMRs, and FTIR. All pure compounds isolated were tested for their cytotoxicity against CEM-SS cell lines, with the Clausine–TH and Clausine–K gave a very strong activity with an IC50 value of 2.1 µg/mL and 5.1 µg/mL, respectively.

7 citations

Journal ArticleDOI
TL;DR: One new xanthone, mesuaferrin C (1), was isolated from the root bark of Mesua ferrea as discussed by the authors, and two other known xanthones which are macluraxanthone (2) and caloxanthone C (3), along with three triterpenoids, � -sitosterol (4), friedelin (5) and betulinic acid (6) were isolated as well.
Abstract: One new xanthone, mesuaferrin C (1), was isolated from the root bark of Mesua ferrea. Two other known xan- thones which are macluraxanthone (2) and caloxanthone C (3), along with three triterpenoids, � -sitosterol (4), friedelin (5) and betulinic acid (6) were isolated as well. The structures of these compounds were determined by 1D and 2D NMR and MS techniques.

7 citations

Journal ArticleDOI
TL;DR: Detailed phytochemical investigation has been carried out on the bark of Artocarpus elasticus Reinw.
Abstract: Detailed phytochemical investigation has been carried out on the bark of Artocarpus elasticus Reinw. ex Blume, which led to the isolation of artonin E (1), a new dihydrobenzoxanthone derivative nam...

6 citations


Cited by
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Journal ArticleDOI
TL;DR: In this paper, a compilation of the 13C NMR data of a selected variety of naturally occurring pentacyclic triterpenoids, arranged skeletonwise, is provided.

1,251 citations

Journal ArticleDOI
TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.
Abstract: Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

800 citations

Journal ArticleDOI
01 May 1949-Nature
TL;DR: The Wealth of India: A Dictionary of Indian Raw Materials and Industrial Products as mentioned in this paper is a dictionary of the economic products of India that was published during the years 1889-99 by the Government of India.
Abstract: IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)

694 citations

Journal ArticleDOI
TL;DR: Findings of beneficial properties of GML's extracts and xanthones isolated from this plant so far are summarized.

654 citations