Mawardi Rahmani

Bio: Mawardi Rahmani is an academic researcher from Universiti Putra Malaysia. The author has contributed to research in topics: Friedelin & Xanthone. The author has an hindex of 24, co-authored 115 publications receiving 1871 citations.

Chemical Constituents and Biological Activities of Glycosmis Chlorosperma Var. Elmeri (Merr.) Stone (Rutaceae)

Abstract: Detailed investigation on the leaves and barks of Glycosmis chlorosperma has led to the isolation and identification of a chalcone, dihydroglychalcone (1) and three sulphones - dambullin (2), sakambullin (3) and methylgerambullin (4), along with the common triterpene, stigmasterol. Compounds (1) (2) and (3) showed cytotoxic activity towards CEM-SS T-lymphoblastic cell lines. However, only dambullin (2) showed activity against pathogenic bacteria and fungi. We wish to report the isolation and bioassay results of the crude extracts and pure compounds.

Studies on the Constituents and Medicinal Properties of Some Zingiberaceous Species

Abstract: Twelve extracts from four Zingiberaceae species (Curcuma xanthorrhiza, Curcuma heyneana, Kaempferia angustifolia and Kaempferia rotunda) have been screened for antimicrobial assay and cytotoxic screening. Curcuma xanthorrhiza showed strong activity in all biological assays. Two cyclohexane diepoxides, crotepoxide and boesenboxide, together with 2'-hydroxy-4,4',6'-trimethoxychaIcone were isolated from the rhizomes of Kaempferia angustifolia. The structure of these compounds were determined by spectroscopic methods such as infrared (IR), nuclear magnetic resonance (A‚¹H, A‚¹A‚³C and 2D NMR) and gas chromatography - mass spectrometry (GC-MS) and by comparison with the data reported previously.

Chemical Constituents of Piper aduncum Linn (Piperaceae)

Abstract: The leaves of Piper aduncum were studied for its chemical constituents. The non-polar component has been identified spectroscopically as dillapiole or 1allyl- 4, 5-methylenedioxy-2, 3-dimethoxybenzene while from the polar fraction 2, 6-dihydroxy-4-methoxydihydrochalcone has been isolated

Chalcone: A Privileged Structure in Medicinal Chemistry.

Abstract: Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

The Wealth of India

Abstract: IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)