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Author

Mawardi Rahmani

Bio: Mawardi Rahmani is an academic researcher from Universiti Putra Malaysia. The author has contributed to research in topics: Friedelin & Xanthone. The author has an hindex of 24, co-authored 115 publications receiving 1871 citations.


Papers
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01 Jan 2013
TL;DR: In this paper, the authors examined the antileukemic activity of Aegle marmelos (leaves, stem bark and roots) against CEM-SS (human T-lymphoblastic leukemia) cancer cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide) assay.
Abstract: Phytochemicals study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7), epoxyauraptene (8) and marmin (9) together with β-sitosterol and stigmasterol All crude extracts and isolated compounds were examined for their antileukemic activity against CEM-SS (human T-lymphoblastic leukemia) cancer cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay Roots extracts exhibited significant cytotoxicity while leaves and stem bark extracts were inactive Hopane triterpenes; zeorin (1) and dustanin (2) as well as alkaloid aegeline (5) isolated from leaves exhibited moderate to strong cytotoxicity with dustanin (2) as the most active constituent (IC50 : 53±024 μg/mL) Lupane triterpenes; epilupeol (3) and lupenone (4), in addition of coumarin derivative; marmin (9) isolated from stem bark also demonstrated moderate to strong cytotoxicity with epilupeol (3) showed significant activity (IC50 : 61±020 μg/mL) The chemical constituents isolated from roots were inactive except for epilupeol (3) and marmin (9) which have also been isolated from stem bark

2 citations

01 Jan 2007
TL;DR: A detiled chemical study on the stem bark extracts of Garcinia nitida has led to the isolation of five xanthones and two triterpenoids as discussed by the authors, which are 1,3,7-trihydroxy-2,4-bis(3-menthylbut-2-enyl)xanthone (1) osajaxanthore, (2) inophylin B, (3) 3-isomangostin, (4) rubraxanthone, (5) stigmasterol and stig masterol
Abstract: A detiled chemical study on the stem bark extracts of Garcinia nitida has led to the isolation of five xanthones and two triterpenoids. They are 1,3,7-trihydroxy-2,4-bis(3-menthylbut-2-enyl)xanthone (1) osajaxanthore, (2) inophylin B, (3) 3-isomangostin, (4) rubraxanthone, (5) stigmasterol and stigmasterol acetate. The structures of these compounds were established using mainly 1D and 2D NMR spectrocopy. Acetylation of rubraxanthone resulted in two new compounds, rubraxanthone monoacetate (6) and rubraxanthone diacetate (7) with rubraxanthone triacetate (8).

2 citations

Journal Article
TL;DR: In this paper, the aerial parts of Tetradium sambucinum (Bl.) Hartley have led to the isolation of decarine, rutaecarpine, aurantiamide acetate and 7-hydroxycoumarin.
Abstract: Detailed extraction and separation of the aerial parts of Tetradium sambucinum (Bl.) Hartley have led to the isolation of decarine, rutaecarpine, aurantiamide acetate and 7-hydroxycoumarin. The structures of the compounds were established by one and two-dimensional A‚¹H- and A‚¹A‚³C-NMR as well other spectroscopic methods. The free radical scavenging and cytotoxic activities were assessed by DPPH assay and against two cancer cell lines, respectively.

2 citations


Cited by
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Journal ArticleDOI
TL;DR: In this paper, a compilation of the 13C NMR data of a selected variety of naturally occurring pentacyclic triterpenoids, arranged skeletonwise, is provided.

1,251 citations

Journal ArticleDOI
TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.
Abstract: Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

800 citations

Journal ArticleDOI
01 May 1949-Nature
TL;DR: The Wealth of India: A Dictionary of Indian Raw Materials and Industrial Products as mentioned in this paper is a dictionary of the economic products of India that was published during the years 1889-99 by the Government of India.
Abstract: IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)

694 citations

Journal ArticleDOI
TL;DR: Findings of beneficial properties of GML's extracts and xanthones isolated from this plant so far are summarized.

654 citations