Mawardi Rahmani

Bio: Mawardi Rahmani is an academic researcher from Universiti Putra Malaysia. The author has contributed to research in topics: Friedelin & Xanthone. The author has an hindex of 24, co-authored 115 publications receiving 1871 citations.

New Flavonoids Derivatives from Artocarpus elasticus with Antioxidant,Antimicrobial and Cyotoxic Activities

Abstract: Detailed investigation on leaves and bark of Artocarpus elasticus has led to the isolation of eight flavonoids derivatives including four new compounds, artoelastil (1), artoelastidi (2), artoelastiq (3), and artoelastidi (4) together with four known compound identified as cycloartocarpesin (5), artonin E (6), cycloartobiloxanthone (7) and artobiloxanthone (8). The structural elucidations of the pure compound were carried out using spectroscopic methods such as UV, IR, NMR, MS and also by comparison with published data. The compounds were tested for their biological activities on antioxidant, cytotoxic, and antimicrobial activities using standard method. Some of the isolated compounds exhibited interesting biological activity which can be further developed as potential antimicrobial, antioxidants and cytotoxic agents.

Alkaloid Constituents of Haplophyllum laeviusculum (Rutaceae) (Kandungan Alkaloid daripada Haplophyllum laeviusculum (Rutaceae))

Abstract: The investigation of the aerial parts of Haplophyllum laeviusculum (Rutaceae), a perennial herb native to Iran, afforded three alkaloids, skimmianine (1), lunamarine (2), ribalinidine (3) and and two common sterols, γ-sitosterol and campesterol. The structures of compounds were identified by using spectroscopic methods by using UV, IR, NMR, MS spectra and also by comparison with previous works. There has been no detail phytochemical investigation report on the plant carried previously. This is the first report on the identification of skimmianine (1), lunamarine (2) from genus Haplophyllum.

Chalcone: A Privileged Structure in Medicinal Chemistry.

Abstract: Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

The Wealth of India

Abstract: IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)