13C NMR spectra of pentacyclic triterpenoids--a compilation and some salient features

Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids

Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

/pdf/chalcone-a-privileged-structure-in-medicinal-chemistry-2glhtivnj7.pdf

Chalcone: A Privileged Structure in Medicinal Chemistry.

IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)

The Wealth of India

http://www.zoranvolleyart.si/images/Mango/01.pdf

Medicinal properties of mangosteen (Garcinia mangostana).

Artosimmin (I) is significantly cytotoxic against cell lines HL-60 and MCF-7 and possesses antioxidant properties towards DPPH

Artosimmin — A Potential Anticancer Lead Compound from Artocarpus odoratissimus.

In a continuing search for xanthones and quinones from the Guttifere family, we decided to look at the genus Crotoxylum A detailed chemical study on Cratoxylum glaucum has led to the isolation of two triterpenoids, friedelin (1) and stigmasterol 9(2), two anthraquinones 1,8-dihydroxy-6-menthoxyanthraquinone (3) and vismiaquinone (4) and one xanthone dimenthymangostin (5) These compounds were identified using the 1D and 2D NMR spectroscopy This is the first report done on the chemistry of Cratoxylum glaucum

Anthraquinones and Xanthones from Cratoxylum glaucum (Guttiferae)

The current investigation was designed to determine the influence of three extraction methods on the 
composition and insecticidal activity of essential oils extracted from Eucalyptus globulus and E. camaldulensis. The evaluated extraction methods were steam-distillation, steam water-distillation and hydro-distillation. Fumigant 
toxicity of the extracted essential oils was evaluated against Sitophilus oryzae. The GC and GC–MS methods were 
used for analyzing the oil chemical composition. Both E. globulus and E. camaldulensis showed significant 
differences in oil yield (w/w, based on dry weight) with direct steam distillation resulting in low oil yields (0.8%; 0.35%) compared to water distillation (2.35%; 2.22%) and water + steam distillation (2.03%; 1. 53%). We identified nineteen compounds in the essential oils of these species. 1, 8-Cineol (27.67-82%), α-Pinene (4.67-8.13%) and Limonene (2.49-10.53%) were the major components of the oils and the highest amount of 1, 8-Cineol (82%) was obtained with water distillation, while steam-distillation resulted in the lowest amount of Cineol (27%). The results of the toxicity study of the essential oils demonstrated that the highest toxicity (LC50 = 24.89 µL/L air) was observed against S. oryzae populations treated with oils extracted by water distillation. In conclusion, the extraction of Eucalyptus essential oils by hydro-distillation had some priorities over the oil extractions by the other methods because hydro-distillation extracted oil had the highest fumigant activity, high and fast-oil yields as well as high percentage composition of 1,8-Cineol.

/pdf/extraction-methods-effects-on-composition-and-toxicity-of-3m3ko4ql63.pdf

Extraction methods effects on composition and toxicity of Eucalyptus essential oil

Arborine (I), a quinazolone alkaloid was isolated from the leaves of Glycosmis pentaphylla (Rutaceae) and was found to have a growth inhibitory effect on the larvae of Drosophila melanogaster.

Arborine, a Larval Growth Inhibitor fromGlycoslnis pentaphylla

The coumarin, 8-methoxycapnolactone and stigmasterol were isolated from the leaves of Micromelum minutum (Rutaceae) which collected from Sepilok, Sabah, Malaysia and their structures were characterized by

Mawardi Rahmani

Papers

Artosimmin — A Potential Anticancer Lead Compound from Artocarpus odoratissimus.

Anthraquinones and Xanthones from Cratoxylum glaucum (Guttiferae)

Extraction methods effects on composition and toxicity of Eucalyptus essential oil

Arborine, a Larval Growth Inhibitor fromGlycoslnis pentaphylla

8-Methoxycapnolactone and stigmasterol From Micromelum minutum 8-Metoksikapnolakton dan stigmasterol dari Micromelum minutum