Mawardi Rahmani

Bio: Mawardi Rahmani is an academic researcher from Universiti Putra Malaysia. The author has contributed to research in topics: Friedelin & Xanthone. The author has an hindex of 24, co-authored 115 publications receiving 1871 citations.

The Chemical Constituents of Ficus benjamina Linn. and Their Biological Activities

Abstract: The leaves, bark and fruits of Ficus benjamina Linn. were subjected to extraction and isolation using chromatographic techniques to yield six compounds (cinnamic acid, lactose, naringenin, quercetin, caffeic acid and stigmasterol). The structures of the compounds were determined by spectroscopic techniques and by comparison with published data. The compounds were screened for antimicrobial activity against two species of bacteria (Bacillus cereus and Pseudomonas aeruginosa) and cytotoxic activity against T-lyrnphoblastic leukemic (CEM-SS) cell line. Caffeic acid exhibited strong cytotoxic activity with IC 50 value of 25 mg/mL.

Coumarins from murraya paniculata (rutaceae)

Abstract: Phytochemical study on leaves of Murraya paniculata have yielded four coumarins of auraptene(1), transgleinadien (2), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumarin (3) and toddalenone(4). The compounds were isolated using chromatographic methods and identified using spectroscopic techniques. Antimicrobial activity evaluation on the crude extracts and pure compounds indicated chloroform extracts of the leaves exhibited moderate activity and only gleinadiene (2)showed moderate activity against Bacillus cereus. trans Isomer of Gleinadiene (2) has never been reported from this plant previously.

Xanthones from Calophyllum gracilipes and Their Cytotoxic Activity (Zanton daripada Calofilum gracilipes dan Aktiviti Ketoksikannya)

Abstract: Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards

Chalcone: A Privileged Structure in Medicinal Chemistry.

Abstract: Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

The Wealth of India

Abstract: IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)