Maxim Shklar

TL;DR: The analyses provide a novel route to infer expression profiles for presumed ancestral nodes in the tissue dendrogram, whereby de novo enhancement and diminution of gene expression go hand in hand, and highlight the importance of gene suppression events.

TL;DR: This work transformed protein structures into residue interaction graphs (RIGs), where amino acid residues are graph nodes and their interactions with each other are the graph edges, and found that active site, ligand-binding and evolutionary conserved residues, typically have high closeness values.

TL;DR: The GeneAnnot system comprehensively documents the many-to-many relationship between oligonucleotide array probesets and annotated genes in GeneCards and performs pairwise alignments between the probe sequences and gene transcripts, and assigns sensitivity and specificity scores to each probeset/gene pair.

TL;DR: GeneTide, the Gene Terra Incognita Discovery Endeavor, is a transcriptome-focused database which aims to enhance GeneCards with additional expressed sequence tag (EST)-based genes by comprehensively mapping >85% of the ∼5.6 million human ESTs currently available at dbEST to known genes by means of data mining and integration of genomic resources including UniGene, DoTS, AceView and in-house resources.

TL;DR: An immediate application of GeneTide to microarray annotation has increased, in a specific example, the number of annotated Affymetrix HGU95A-E probe sets by 50% in comparison to previous attempts.